空腹血糖受损与颈动脉内膜中层厚度无关  

Impaired fasting glucose may not relate to the carotid intima-media thickness

作　　者：李雯[1] 刘雪梅[1] 黄玮[1] 李晓庆[1] 刘星[2] 李俊娟[2] 梁洁[2] 吴寿岭[2] 

机构地区：[1]河北联合大学附属开滦总医院超声科,河北唐山063000 [2]河北联合大学附属开滦总医院心内科,河北唐山063000

出　　处：《中华高血压杂志》2013年第8期759-762,共4页Chinese Journal of Hypertension

基　　金：国家科技重大专项课题(2008ZX09312-008-004)

摘　　要：目的探讨空腹血糖受损（IFG）对颈动脉内膜中层厚度（CIMT）的影响。方法于2010—2011年随机分层抽取唐山开滦（集团）有限责任公司在职及离退休职工中≥40岁、既往无脑卒中、短暂性脑缺血发作、心肌梗死者共5852人为调查对象，最终纳入统计分析的共5392人，进行统一问卷调查、血液生化及颈动脉超声检查。根据2003年美国糖尿病协会IFG诊断标准将研究对象分为3组：理想血糖组（空腹血糖〈5．6mmol／L，n=3652）、IFG组（空腹血糖5．6～〈7．0mmol／L，n=1236）和糖尿病组（空腹血糖≥7．0mmol／L，n=504）。采用多因素Logistic回归分析IFG对CIMT的影响。结果糖尿病组CIMT均值高于理想血糖组和IFG组（0．90比0．81、0．82mm，均P％0．05），IFG组CIMT高于理想血糖组，但差异无统计学意义（P〉0．05）。多因素Logistic回归分析显示，调整其他危险因素后，IFG与CIMT增厚无关（OR 0．929，95％CI 0．757～1．140，P〉0．05）。结论IFG可能与CIMT增厚无关。Objective To study the effect of impaired fasting glucose （IFG） on carotid intima-media thickness （CIMT）. Methods From 2010 to 2011, 5852 current and retired workers in Tangshan Kailuan group aged 40 and over and without previous stroke, transient ischemic attack and myocardial infarction were selected by stratified random sampling. Among them, 5392 were finally enrolled in the statistical analysis. All datas were obtained from a unified questionnaire, blood biochemistry test and carotid artery ultrasonography. Based on IFG diagnostic criteria of the American Diabetes Association in 2003, the subjects were divided into three groups：ideal blood glucose group （fasting blood glucoseS5.6 mmol/L, n=3652）, IFG group （fasting glucose 5.6-〈7.0 mmol/L, n=1236） and diabetic group （fasting blood glucose 97 mmol/L, n= 504）. Multivariate Logistic regression analysis was used to analyze the effect of IFG on CIMT. Results The mean value of CIMT in diabetic group was higher than those in i- deal blood glucose group and IFG group （0.90 vs 0.81, 0.82 mm; both P〈0.05 ）. The mean value of CIMT in IFG group was higher, but not significantly than that in ideal blood glucose group （P〉0.05）. After adjusted for other risk factors, multivariate Logistic regression analysis showed that IFG had no correlation with the increase of CIMT （OR 0. 929, 95% C10. 757-1. 140, P〉0.05）. Conclusion IFG may not relate to the increase of CIMT.

关 键 词：空腹血糖受损 颈动脉 内膜中层厚度 

分 类 号：R587.1[医药卫生—内分泌]