半导体激光对人体穴位外照射及家兔血管内照射后对SOD、LPO及GSH、GSH-PX的影响  

The Effects on SOD、LPO & GSH、GSH-PX Affected by Diode Laser Acupuncture or ILIB

作　　者：成侃[1] 王懿[1] 占世坤[1] 胡秉诚[1] 高岷[2] 金慧芳[2] 王如瑶[2] 成柏华[2] 

机构地区：[1]上海第二医科大学附属瑞金医院,神经外科200025 [2]上海第二医科大学,200025

出　　处：《激光生物学报》2000年第1期46-49,共4页Acta Laser Biology Sinica

基　　金：国家自然科学基金资助项目!(编号 :694780 2 5 )

摘　　要：活性氧等自由基对机体可以影响许多生理和病理的过程 ,并认为在诱发某些疾病的机制上起着关键作用。本工作主要以半导体激光取代氦氖激光 ,体外穴位外照射取代血管内照射 ( ILIB)以观察激光对体内SOD、LPO( MDA)、GSH及 GSH-PX的影响。实验结果提示 :半导体激光 ( 650 nm,1 0～ 1 5m W,CW)照射人体“扶突”穴位后 ,可以即刻非常显著地提高血清 SOD的活性 ( P<0 .0 0 5)。这将有效地即刻提高机体清除氧自由基的能力 ,改进当前的临床治疗方法 (血管内照射 )以及免除患者的血管损伤 ,细菌感染等等的作用 ,再加仪器更轻巧 ,故在临床应用上具有很重要的应用价值。在过氧化脂质 LPO( MDA)方面 ,虽亦见有相应减少的倾向 ,但不显著。在 GSH及 GSH-PX的抗氧化体系中 ,激光对它影响似乎不大。本工作还对家兔进行了模拟血管内照射的观察 ,在 SOD、LPO方面亦有类似倾向 ,但均未达显著性差异。可能与方法及剂量等因素有关。Free radical of oxygen is an important factor which influencing the physiological and pathological metabolism in human body,usually look as an initiator in diseases. In this paper the SOD,LPO (MDA),and GSH,GSH-PX were observed by the diode laser irradiated on the acupoints in human body or ILIB on the rabbit blood vessel. The results showed that the diode laser (650 nm,10～15mW,CW) irradiating on the "Futu" acupoints bilaterly in human body could be immediately enhancing the level of serum SOD significantly (P<0.005).It means that the ability of cleaning the free radicals is available.Moreover,it also would be to improve the treatment method in clinical instead of ILIB,avoiding the injure on blood vessel or infections.So it is important and useful in clinical therapy. In LPO(MDA)it also showen a decreasing tendency,and in GSH,GSH-PX system,it showed a less effective.

关 键 词：半导体激光 穴位照射 血管内照射 氧自由基 SOD 

分 类 号：R454.2[医药卫生—治疗学] Q682[医药卫生—临床医学]