中国汉族人群CXCR2基因+1235C/T多态与急性冠脉综合征的关联研究  

Correlation Between CXCR2 +1235C/T Polymorphism and Acute Coronary Syndrome in Han Population of China

作　　者：张效林[1] 张保海[1] 梁振洋[1] 孙莹[1] 冯雪瑶[1] 李晓燕[2] 韩雅玲[1] 

机构地区：[1]沈阳军区总医院心内科,辽宁沈阳110084 [2]济南军区总医院心内科,山东济南250031

出　　处：《现代生物医学进展》2013年第22期4305-4308,共4页Progress in Modern Biomedicine

基　　金：国家军队高新技术重大项目(2010GXJS001);国家自然科学基金青年科学基金项目(81100135)

摘　　要：目的:炎症反应在动脉粥样斑块变化的病理过程中发挥着重要的作用。本研究探讨CXCR2基因+1235 C/T单核苷酸多态与中国汉族人群急性冠脉综合征发病的相关关系。方法:本研究采用聚合酶链反应-限制性片段长度多态性方法对675例急性冠脉综合征的患者和636例对照组进行检测,分析CXCR2基因+1235 C/T单核苷酸多态的基因型和等位基因频率的分布情况,同时收集济南军区总医院心内科经冠脉造影证实为阳性的急性冠脉综合征患者360例及对照者360例,对上述关联分析的结果进行复制实验的印证。结果:CXCR2基因+1235 C/T单核苷酸多态三种基因型(CC型,CT型和TT型)在急性冠脉综合征组分布频率分别为39.3%,45.3%和15.1%,在对照组分别为41.7%,47.2%和11.1%,CXCR2基因+1235 C/T基因型和等位基因频率对照组和急性冠脉综合征组之间存在统计学差异(P<0.05)。Logistic回归校正性别、年龄、体重指数、吸烟、高血压、高脂血症、糖尿病等冠心病的易患因素后,CXCR2基因+1235 C/T多态与急性冠脉综合征的发病存在相关关系(P<0.05)。结论:CXCR2基因+1235 C/T多态与急性冠脉综合征发病存在相关关系,CXCR2基因+1235 C/T多态可能是中国汉族人群急性冠脉综合征发病的独立危险因子。Objective： In recent years,CXCR2 a proinflammatory cytokine receptor involved in both innate and acquired immune responses,plays a key role in the development of atherosclerosis plaque.CXCR2 has been suggested to play an important role in coronary arterial disease and its sequelae.The aim of the present study was to investigate the association between CXCR2 ＋1235C/T polymorphism and acute coronary syndrome in Han population of China.Methods： A case-control study was conducted in 675 patients with acute coronary syndrome and 636 control who had normal coronary angiograms.Polymorphic genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.The association was confirmed in the second population from the General Hospital of Jinan Military Area Command.Results： The genotype frequencies in CXCR2 ＋1235C/T polymorphism conformed well to the Hardy-Weinberg equilibrium in both case and control group.The genotype frequencies of CC,CT and TT of CXCR2 ＋1235C/T polymorphism were 47.1 %,47.2 % and 11.1 % in the controls,35.9 %,45.3 % and 15.1 % in acute coronary syndrome patients respectively.There were significant differences in the genotype and allele distribution of ＋1235C/T polymorphism of the CXCR2 gene between cases and controls（P0.05）.Logistic regression analysis with adjustments for other risk factors revealed that the CXCR2 ＋1235C/T allele carriers significantly increases the risk of acute coronary syndrome compared with the non-carriers（P 0.05）.Conclusion： This study shows that the CXCR2 ＋1235C/T polymorphism may be considered a genetic risk factor for acute coronary syndrome in Han population of China.

关 键 词：冠心病 急性冠脉综合征 基因 单核苷酸多态性 

分 类 号：R541.4[医药卫生—心血管疾病]