抑郁症患者血清IFN-γ、IL-10水平与NGF、NT-3的相关研究  

Study on the correlation of serum levels of IFN-γ,IL-10with NGF,NT-3in depression patients

作　　者：郑蕾[1] 王艺明[1] 

机构地区：[1]贵阳医学院附属医院心理科,贵州贵阳550004

出　　处：《贵州医药》2013年第7期592-593,共2页Guizhou Medical Journal

基　　金：贵州省科技计划基金资助项目[黔科合SY字(2008)3063号];贵阳市科学技术计划基金资助项目[筑科农合同字(2009)第3-008号]

摘　　要：目的研究抑郁症患者血清干扰素-γ(IFN-γ)和白介素10(IL-10)与血清神经生长因子(NGF)、神经营养因子3(NT-3)是否相关。方法采用酶联免疫吸附试剂对31例抑郁症患者血清IFN-γ和、IL-10、NGF、NT-3水平进行检测。结果抑郁症血清IFN-γ水平与NGF呈正相关(P<0.05),患者血清IL-10水平与NT-3呈正相关(P<0.05)。结论抑郁症患者血清神经营养因子水平的变化与细胞因子的变化有关。Objective To investigate the serum levels of IFN-y and IL-10 in patients with depres- sion,and analyze any possible correlation of IFN-γ, IL-10 with NGF, NT-3 . Methods The levels of IFN-γ, IL-10, NGF, NT-3 were evaluated by ELSIA in 31 patients. Results It was found that the ser- um level of IFN-γ was correlated with level of NGF （P〈0.05）. The serum level of IL-10 was correla- ted with level of NT-3 （P〈0.05）. Conclusion The data suggest that the immunity activating response of depression patients influence the serum level of neurotrophic factors.

关 键 词：抑郁症 血清干扰素-Γ 白介素-10 血清神经生长因子 神经营养因子-3 

分 类 号：R33[医药卫生—人体生理学]