162例次丙戊酸血药浓度监测结果与分析  

Monitoring of Plasma Concentration of Valproic Acid:Analysis of 162 Cases

作　　者：万涛[1] 袁孔现[1] 周方杰[1] 朱虹[1] 刘记[1] 凌艳[1] 詹三华[1] 

机构地区：[1]铜陵市人民医院,安徽铜陵244000

出　　处：《中国医院用药评价与分析》2013年第8期717-719,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:通过监测患者丙戊酸血药浓度,为临床合理用药提供参考依据。方法:采用柱前衍生-高效液相色谱法对162例次癫痫患者服用丙戊酸钠进行血药浓度监测,并对结果进行回顾性分析。结果:83例次监测结果在有效浓度范围(50～100 mg/L)内,占总例次数的51.2%;低于治疗浓度范围下限(<50 mg/L)的63例次,占总例次数的38.9%;高于治疗浓度范围上限(>100mg/L)的16例次,占总例次数的9.9%。结论:丙戊酸血药浓度个体差异大,监测患者丙戊酸血药浓度十分必要。OBJECTIVE：To monitor the plasma concentration of valproic acid in patients so as to provide reference for clinical rational use of drug. METHODS： The serum concentrations of valproic acid of 162 cases were determined by pre-column derivatization-high performance liquid chromatography, and the results were analyzed retrospectively. RESULTS： The monitoring results were within the effective concentration range （50-100 mg/L ） in 83 cases （51.2% ）, below the therapeutic concentration range lower limit （ 〈 50 mg/L） in 63 cases （38.9%） and higher than the therapeutic concentration range upper limit （ 〉 100 mg/L） in 16 cases （9.9%）. CONCLUSION： There were big individual differences in terms of the plasma concentration of valproic acid, thus monitoring of plasma concentration of valproic acid is necessary.

关 键 词：丙戊酸 血药浓度监测 柱前衍生-高效液相色谱法 

分 类 号：R971.6[医药卫生—药品]