129例药品不良反应/事件报告分析  

Adverse Drug Reactions/Adverse Drug Events:Analysis of 129 Cases

作　　者：李蕊[1] 

机构地区：[1]航天中心医院药剂科,北京100049

出　　处：《中国医院用药评价与分析》2013年第8期735-737,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解药品不良反应/事件(ADR/ADE)发生的特点和危害,探讨ADR/ADE的防护措施,促进临床合理用药。方法:收集航天中心医院2009年1月—2012年12月的129例ADR/ADE报告,按因果关系判断标准进行回顾性分析与统计。结果:129例ADR/ADE报告中,男女比例为1∶2;静脉给药是引发ADR/ADE的主要给药方式;共涉及药品82种,引起ADR/ADE例次数最多的为抗感染药,共25种,其次为中成药,共24种;ADR/ADE累及器官和(或)系统以胃肠系统最为常见;原患疾病排第1位的是支气管炎。结论:临床应重视ADR/ADE的监测和报告工作,全方位加强ADR/ADE报告意义的宣传,提高认识,以减少和避免ADR的发生,保证药物应用安全、有效。OBJECTIVE：To investigate the characteristics and hazard of the adverse drug reactions/events （ADR/ ADE）, explore the prevention of ADR/ADE so as to promote rational use of drug. METHODS： A total of 129 ADR/ADE cases collected in our hospital from Jan. 2009 to Dec. 2012 were statistically analyzed using the evaluation criteria for causality. RESULTS： Of the 129 ADR/ADE cases, the ratio of male/female was 1 ： 2. The ADR/ADE was mainly induced via intravenous administration. A total of 82 drugs were involved in the ADR/ADE, with anti-infective drugs （25 anti-infective drugs） topping the list in terms of number of ADR/ADE cases, followed by Chinese patent drugs （24 Chinese patent drugs）. The ADR/ADE occurred mainly in gastrointestinal system. The primary disease topping the list in ADR/ADE cases was bronchitis. CONCLUSION： ADR/ADE reporting and monitoring should be strengthened in clinic. It is important to strengthen publicizing of the importance of ADR/ADE reporting and deepen understanding on ADR/ADR so as to reduce and avoid the occurrence of ADR/ADE and ensure safe and effective medication.

关 键 词：药品不良反应 事件 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]