268例药品不良反应报告分析  

Adverse Drug Reaction Reports:Analysis of 268 Cases

作　　者：肖凌[1] 赵继红[1] 沈司京[1] 

机构地区：[1]北京大学首钢医院药剂科,北京100144

出　　处：《中国医院用药评价与分析》2013年第8期747-749,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解药品不良反应(ADR)发生的特点及规律。方法:对2011年北京大学首钢医院收集的268例ADR报告进行分类、统计与分析。结果:268例ADR中,男性(139例)发生率略高于女性(129例),>60岁的患者ADR发生率较高(147例,占54.85%);静脉滴注给药较其他给药途径更易引发ADR(199例,占74.26%);抗病原微生物药引发的ADR最多(110例,占41.05%),其次是循环系统用药(41例,占15.30%);累及器官和(或)系统及临床表现以皮肤及其附件损害最为常见(137例,占51.12%)。结论:应加大ADR监测,通过ADR监测工作,了解ADR发生的特点及规律,降低ADR发生率,为临床安全用药提供参考。OBJECTIVE ：To investigate the characteristics and regular patterns of adverse drug reactions （ADRs）. METHODS ： 268 ADR cases collected in Peking University Shougang Hospital during 2011 were classified and analyzed statistically. RESULTS ： The ADRs occurred more often in males than in females of the total 268 cases （ 139 cases vs. 129 cases） and in patients aged 〉 60 years （ 147 cases, 54. 85% ）. The ADRs were mostly induced by intravenous drip infusion （199 cases, 74.26% ）, by antimicrobial drugs （110 cases, 41.05% ） and drugs for circulatory system （41 cases, 15.30% ）; the ADRs manifested mostly as damage of skin and appendants （ 137 cases, 51.12% ）. CONCLUSION： ADR monitoring should be emphasized so as to familiarize the characteristics and regular patterns of ADR and reduce the incidence of ADR for clinical reference of safe medication.

关 键 词：药品不良反应 报告 分析 合理用药 

分 类 号：R969.3[医药卫生—药理学]