aac(6')-Ib-cr基因是微生物对喹诺酮类抗菌药的又一耐药途径  

Aac (6')-Ib-cr Gene is Another Way of Quinolone Antibiotic Microbial Resistance

作　　者：谭蓉[1] 郑志昌[1] 杨继红[1] 孙为民[1] 宋琪雯[1] 

机构地区：[1]贵阳医学院附属医院药剂科,贵州贵阳550004

出　　处：《药品评价》2013年第16期15-16,35,共3页Drug Evaluation

摘　　要：aac(6')-Ib-cr基因表达的氨基糖苷乙酰转移酶通过质粒介导方式对环丙沙星等乙酰化,使其抗菌生物活性降低,并与其他耐药因素产生协同作用,导致MIC值大幅升高。该基因分布范围广,检出率高,使得微生物对喹诺酮类抗菌药物耐药更加复杂。本文检索了近年来aac(6')-Ib-cr基因相关研究报道,归纳论述该基因在喹诺酮类抗菌药物耐药中的作用,提醒临床医务工作者应高度重视aac(6')-Ib-cr基因对临床用药的影响,以促进喹诺酮类抗菌药的合理应用。Aminoglycoside acetyl transferase,expressed by a variant of the gene encoding aminoglycoside acetyltransferase AAC（6’）-Ib,can reduce the activity of fluoroquinolones by N-acetylation at the amino nitrogen on its piperazinyl substituent.The gene is in a wide range of distribution and has a high detection rate.The enzyme,which has a synergistic effect with other resistance factors,can increase the MIC value significantly.All of these make the fluoroquinolone resistance more complex.Based on the above literatures reported about AAC（6’）-Ib-cr gene,the gene in quinolone antibiotics drug resistance was summarized.Clinical staffs should pay high attention to the effect of aac（6’）-Ib-cr gene on the outcomes of clinical pharmacotherapy so as to promote the rational use of quinolones.

关 键 词：aac(6’)-Ib-cr基因 氨基糖苷乙酰转移酶 喹诺酮类抗菌药物 抗菌药物耐药 

分 类 号：R965.2[医药卫生—药理学]