糖尿病大鼠组织中微量元素的仪器中子活化分析  

Determination of trace elements in tissues of diabetic rats by INAA

作　　者：谈明光[1] 王荫淞[1] 钱银娥[1] 张桂林[1] 张洪德[2] 王煜飞[2] 葛永新[2] 

机构地区：[1]中国科学院上海原子核研究所,上海201800 [2]上海市第一人民医院,上海200080

出　　处：《核技术》2000年第10期735-738,共4页Nuclear Techniques

基　　金：国科学院"九五"重大项目!(21089751)

摘　　要：使用链脲佐菌素诱导出大鼠的Ⅰ型糖尿病（ＩＤＤＭ）模型，以正常大鼠作对照。用仪器中子活化分析法测定了大鼠的肝、肾和胰腺组织中Ａｓ、Ｂｒ、Ｃａ、Ｃｏ、Ｃｌ、Ｃｕ、Ｆｅ、Ｈｇ、Ｍｇ、Ｍｎ、Ｎａ、Ｒｂ、Ｓ、Ｓｅ和Ｚｎ等元素的含量．结果表明，ＩＤＤＭ大鼠模型的这３种组织中的一些微量元素含量发生了明显改变．并对这些元素含量发生变化的原因和意义作了讨论。By using streptozotocin (STZ) injection to induce model diabetic rats, instrumental neutron activation analysis was applied to analyze elemental concentrations in liver, kidney and pancreas tissues in diabetis and control rats. Results obtained for As, Br, Ca, Co, Cl, Cu, Fe, Hg, Mg, Mn, Na, Rb, S, Se and Zn in those tissues show that some elemental contents in diabetic group change obviously when compared with those of the controls. The changes of elemental contents and their significance are discussed.

关 键 词：糖尿病 微量元素 仪器中子活化分析 

分 类 号：R587.1[医药卫生—内分泌]