应用放射自显影术观察^(99m)Tc-MIBI在大鼠甲状腺内的动态分布  

Autoradiographic Observation on distribution of ^(99m)Tc-MIBI in rat thyroid

作　　者：刁尧[1] 邢福琴[1] 

机构地区：[1]中国医科大学同位素中心实验室,沈阳110001

出　　处：《核技术》2000年第11期805-808,共4页Nuclear Techniques

摘　　要：报道了９９ｍＴｃ－ＭＩＢＩ在大鼠甲状腺内的动态分布。结果显示，甲状腺摄取９９ｍＴｃ－ＭＩＢＩ高 峰在注药后３—６０ｍｉｎ，其前３ｍｉｎ主要与血供有关。１５—６０ｍｉｎ是腺体摄取的主要过程，为浓聚 滞留时间，注药后６０ｍｉｎ内单位重量甲状腺组织摄取放射性大于同时间其它脏器和组织。放射 自显影结果显示，在甲状腺滤泡细胞周边部即上皮细胞及其周围银颗粒分布致密，而在滤泡腔 内的胶质和滤泡间质内很少或基本未见银颗粒。随着时间的推移，银颗粒在滤泡细胞内的分布 规律不变，银颗粒的集聚与甲状腺滤泡所处的功能状态相一致。Distribution of 99mTc-MIBI was studied in frozen section of rat thyroid tissue using autoradiography and γ counter detector at different times after cauda vein injection. The results demonstrated that the ability of thyroid to uptake 99mTc-MIBI was strongest at 3 minute after injection and the speed of excretion was slow in the period from 15 to 60 minutes and thus formed the retention period with the highest concentration. 99mTc-MIBI was rapidly eliminated after 60 minutes and autoradiographic film exhibited that large amount of 99mTc-MIBI distributed in follicular epithelial cells especilly in basal part.

关 键 词：^(99m)Tc-MIBI 甲状腺 放射自显影 

分 类 号：R817.46[医药卫生—影像医学与核医学] R817.1[医药卫生—放射医学]