朝鲜族和汉族男性血清γ-谷氨酰转移酶与多种代谢异常患病危险的相关性  

Relationship between gamma-glutamyl transferase and the risks for multiple metabolic disorders in Korean-Chinese and Han nationality men

作　　者：朴鲜女[1] 金乃星[2] 许梅花[2] 方今女[3] 

机构地区：[1]延边大学附属医院心内科 [2]延边大学护理学院 [3]延边大学医学院预防医学教研部,吉林延吉133000

出　　处：《延边大学医学学报》2013年第2期115-119,共5页Journal of Medical Science Yanbian University

基　　金：国家自然科学基金项目(30260098;30860244);吉林省教育厅基金项目(2008-2)

摘　　要：[目的]分析延边地区朝鲜族和汉族男性血清γ-谷氨酰转移酶（GGT）与多种代谢性疾病患病危险的相关性．[方法]于2009年7月2010年7月间在延边地区安图县采用整群抽样方法选取30～70岁的朝鲜族和汉族男性人群3416例，所有研究对象对调查内容均知情同意．选择研究对象时，排除其他民族及混血民族学生以便更准确地比较民族之间的差异性．采用标准化调查表收集本研究相关信息．通过健康体格检查准确测量身高、体重、腰围、血压，同时抽取清晨空腹（禁食12h）静脉血，准确测定清晨空腹（禁食12h）静脉血GGT、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）及血糖（FBG），并分析GGT与多种代谢指标的相关性．[结果]随着GGT水平的升高，整体型肥胖、腹型肥胖、高血压、高TC、高TG及高血糖（汉族）的检出率呈显著增加趋势（P〈O．01）；朝鲜族与汉族男性GGT水平随着多种代谢异常聚集程度的增加呈增高趋势，其增高趋势有统计学意义（P〈0．01）．[结论]延边地区朝鲜族和汉族男性多种代谢异常者检出率与GGT水平的升高有相关性．OBJECTIVE To analyze the relationship between gamma-glutamyl transferase （GGT） and the risks for multiple metabolic disorders in Korean-Chinese and Han nationality men of Yanbian area METHODS By using a cluster sampling method, 3 416 subjects （1 848 of Korean-Chinese, 1 618 of Han nationality）, 30 70 years of age, were selected from July, 2009 and July, 2010, and all subjects knew the informed consent. At choosing the subjects, other ethnic and hybrid ethnic students were excluded in order to more accurately compare the differences between two ethnic groups. The relevant informations were collected by the standardized questionnaire. Physical examination was carried out in the early morning after 12 hour fasting, and the height, weight, waist circumference, blood pressure, and the serum GGT, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, fasting blood glucose （FBG） were measured by using the standardized methods, and the relationship between GGT and multiple metabolic indexes was analyzed. RESULTS The detection rates of overall obesity, central obesity, hypertension, high （Han nationality） TC, high TG, hyperglycemia were progressively higher with increases of average GGT. The average level of GGT was increased along with the increment of metabolic disorder numbers in both nationalitiesCONCLUSION The detection rates of average GGT, and the average numbers of multiple GGT was metabolic disorders were progressively higher with increase increased along with the increment of metabolic disorder

关 键 词：Γ-谷氨酰转肽酶 代谢异常 相关性 民族 

分 类 号：R589[医药卫生—内分泌]