血液灌流联合血液透析对慢性肾脏病终末期患者β2-微球蛋白、Leptin、甲状旁腺素水平及生存质量的影响  

Effect of hemoperfusion and hemodialysis on levels of β2-microglobulin, leptin and parathyroxin and quality of life in patients with end-stage chronic kidney disease

作　　者：李仪[1] 罗海凤[1] 刘绮虹[1] 胡浩强[1] 莫文辉[1] 刘国辉[1] 

机构地区：[1]广东省东莞市人民医院普济肾内科,广东东莞523000

出　　处：《广东医学院学报》2013年第1期19-20,29,共3页Journal of Guangdong Medical College

摘　　要：目的了解血液灌流(HP)联合血液透析(HD)对慢性肾脏病终末期患者β2-微球蛋白、Leptin、甲状旁腺素水平及生存质量的影响。方法 62例慢性肾脏病终末期患者随机分HD组(32例)、HP+HD组(30例),比较两组患者治疗前后血清β2-微球蛋白、Leptin、甲状旁腺素水平及生存质量的差异。结果 HP+HD组在总体健康状况、体能、疼痛、社会功能、精力状况及甲状旁腺素、β2-微球蛋白及Leptin清除方面优于HD组(P<0.01或0.05);而在体力所致工作生活受限、情感状况方面差异无统计学意义(P>0.05)。结论 HP联合HD可改善慢性肾脏病终末期患者生理、心理、社会等方面的功能,提高生活质量。Objective To investigate the effect of hemoperfusion （HP） and hemodialysis （HD） on levels of β2-microglobulin, leptin and parathyroxin and quality of life in patients with end-stage chronic kidney disease （CKD）. Methods Sixty-two patients with end-stage CKD were randomly divided into HD （n=32） and HP＋HD （n=30） groups. Serum levels of β2-microglobulin, leptin and parathyroxin and quality of life were compared before and after treatment in both groups. Results Total health condition, physical ability, pain, social function, stamina, and clearance of β2-microglobulin, leptin and parathyroxin in HP＋HD group were superior to those in HD group （P0.01 or 0.05）, but the difference was insignificant in emotion condition and hypodynamia-induced limitation of life and work between both groups （P0.05）. Conclusion HP＋HD can improve the physiological, psychological and social functions and quality of life in patients with end-stage CKD.

关 键 词：血液透析 血液灌流 生活质量 慢性肾脏病 

分 类 号：R692.5[医药卫生—泌尿科学]