丙型肝炎病毒核心抗原检测对HCV感染诊断的意义  

The significance of hepatitis C virus core antigen detection for HCV infection diagnosis

作　　者：向明确[1] 潘菁[1] 何茂锐[1] 杨鸿[1] 谢雪梅[1] 谢伶华[1] 曹永平[1] 

机构地区：[1]重庆市第九人民医院感染科,重庆400700

出　　处：《国际检验医学杂志》2013年第15期1928-1929,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨丙型肝炎病毒核心抗原(HCV-cAg)检测对丙型肝炎病毒(HCV)感染诊断的价值。方法随机选取于该院检验科做HCV抗体(HCV-Ab)检测的215例血液标本,采用试剂盒进行检测,首先检测HCV-Ab,根据HCV-Ab检测结果分为HCV-Ab阳性组和HCV-Ab阴性组。同时检测两组的游离HCV-cAg、总HCV-cAg、HCV-RNA。结果 HCV-Ab阳性组(97例)中,游离HCV-cAg阳性占25.8%(25/97),总HCV-cAg阳性占71.1%(69/97),HCV-RNA阳性占68.4%(66/97);HCV-Ab阴性标本组(118例)中,游离HCV-cAg阳性占1.7%(2/118),总HCV-cAg阳性占2.5%(3/118),HCV-RNA阳性占1.7%(2/118)。结论 HCV-cAg的检测有利于HCV感染的早期诊断。Objective To investigate the value of the hepatitis C virus core antigen（HCV-cAg） detection for the diagnosis of hepatitis C virus（HCV） infection. Methods 215 cases of hepatitis C antibody（HCV-Ab） test specimen in the hospital were collected for the study. Test kits were used to detect HCV-Ab firstly,then the specimen were divided into HCV-Ab positive group and negative group,for which free HCV-cAg,total HCV-cAg, HCV-RNA were detected at the same time. Results There were 97 cases of HCV-Ab positive, free HCV-cAg positive accounted for 25. 8% （25/97）, the total HCV-cAg positive 71. 1% （69/97）, HCV-RNA positive 68.4% （66/97） ;there were 118 cases of HCV-Ab negative, free HCV-cAg positive accounted for 1. 7 %（2/ 118） ,the total HCV-cAg positive 2.5%（3/118）,HCV-RNA positive 1.7%（2/118）. Conclusion HCV-cAg test is useful for early diagnosis of HCV infection.

关 键 词：肝炎 丙型 肝炎抗体 丙型 肝炎抗原 丙型 

分 类 号：R446.6[医药卫生—诊断学]