类风湿关节炎患者外周血CD4^+CD25^(high)调节性T细胞测定及意义  

Detection and significance of CD4^+CD25^(high) Treg in the peripheral blood of patients with newly diagnosed rheumatoid arthritis

作　　者：汤珂珂[1] 邱夏桑[1] 高祖华[1] 

机构地区：[1]台州医院,浙江省临海317000

出　　处：《现代实用医学》2013年第8期849-850,853,F0003,共4页Modern Practical Medicine

基　　金：浙江省医药卫生科技计划项目(2011KYA160);浙江省台州市科技计划项目(11KY03);浙江台州恩泽医疗中心(集团)科学研究基金项目(11EZD24)

摘　　要：目的探讨CD4+CD25high调节性T细胞(CD4+CD25highTreg)在类风湿性关节炎(RA)发病机制中的作用。方法采用流式细胞仪(FCM)检测42例RA患者及23例健康对照组外周血CD4+CD25highTreg的数量。结果 RA患者组及对照组外周血CD4+CD25highTreg的表达为(2.69±1.85)%和(3.83±0.89)%,RA患者组CD4+CD25highTreg的表达低于对照组,差异有统计学意义(<0.01)。结论 RA组患者CD4+CD25highTreg表达下降。Objective To investigate the role of CD4＋CD25high regulatory T cells （CD4＋CD25high Treg） in the pathogenesis of rheumatoid arthritis （RA）. Methods Forty-two cases of patients with rheumatoid arthritis and 23 healthy controls were selected to detect the number of peripheral blood CD4＋CD25high Treg by flow cytometry （FCM）. Results The CD25high expressions in peripheral blood CD4＋ lymphocyte of RA patients and control groups were （2.69±1.85） % and （3.83±0.89） %, respectively. The expression of CD4＋CD25high Treg in patients with rheumatoid arthritis was significantly lower than that of healthy cases（P 〈 0.01）. Conclusions The expression ofCD4＋CD25high Treg of rheumatoid arthritis patients decreased.

关 键 词：关节炎 类风湿 C 

分 类 号：R392.11[医药卫生—免疫学] R593.22[医药卫生—基础医学]