透明背脊皮翼视窗在肿瘤活体成像中的应用  

The applications of tumor in vivo imaging by using transparent dorsal skin fold window chamber

作　　者：许改霞[1] 翟鹏[2] 林苏霞[2] 饶南熹[1] 朱小妹[1] 王晓梅[2] 牛憨笨[1] 

机构地区：[1]深圳大学光电工程学院,光电子器件与系统教育部/广东省重点实验室,深圳518060 [2]深圳大学医学院,深圳市生物医学工程重点实验室,深圳518060

出　　处：《深圳大学学报（理工版）》2013年第5期518-526,共9页Journal of Shenzhen University(Science and Engineering)

基　　金：国家重点基础研究发展计划资助项目(2012CB85802);广东省科技创新资助项目(2012KJCX0094)~~

摘　　要：综述一种新型活体光学成像辅助工具背脊皮翼视窗的历史沿革,介绍背脊皮翼视窗的构建和基于背脊皮翼视窗的活体光学成像系统,阐述其在肿瘤活体成像研究中的应用,结合本课题组研究指出背脊皮翼视窗在原位、实时、长时间肿瘤血管增生及相关肿瘤机制研究中有广阔的应用前景.This paper introduces the history and characteristics of dorsal skin fold window chamber （ DSFC）, a novel optical in vivo imaging auxiliary tool. Then, the construction and the optical in vivo imaging systems based on the DSFC are summarized. The main applications for tumor optical in vivo imaging of DSFC are presented. Finally, it is pointed out that the DSFC has great potential for cancer angiogenesis and the mechanism of cancer development by in situ, real-time and long-term optical in vivo imaging.

关 键 词：生物物理学 背脊皮翼视窗 活体成像 光学成像 肿瘤研究 血管增生 

分 类 号：R332[医药卫生—人体生理学]