血必净注射液对创伤性急性肺损伤患者HMGB1水平的影响及其治疗价值  

Effect of Xuebijing injection on the serum high mobility group box-1 protein level of patients after traumatic acute lung injury

作　　者：汤鲁明[1] 王林霞[1] 孙来芳[1] 王志翊[1] 陈大庆[1] 李忠旺[1] 

机构地区：[1]温州医学院附属第二医院急救中心,浙江温州325027

出　　处：《中国现代医生》2013年第26期57-59,共3页China Modern Doctor

基　　金：浙江省温州市第一期科技计划项目(Y20120108);浙江省医药卫生科技计划(2013RCA039)

摘　　要：目的探讨血必净注射液对创伤性急性肺损伤患者血清高迁移率族蛋白B1水平的影响。方法将50例创伤性急性肺损伤患者随机分成两组,常规组给予常规治疗,血必净组在常规治疗基础上加用血必净注射液100 mL,Q12 h;治疗前及治疗后7 d,利用酶联免疫吸附法检测外周血HMGB1浓度,同时监测血气分析,记录治疗前后急性生理学与慢性健康状况Ⅱ(acute physiology and chronic health evaluation,APACHE-Ⅱ)评分、pH值及氧合指数。结果两组患者24 h内血清HMGB1浓度较正常健康组显著升高;治疗7 d后,与常规组相比,血必净组血清HMGB1下降更为明显(P<0.05);血必净组较常规组pH值、氧合指数改善更为显著(P<0.05);两组死亡率及ARDS发生率无明显差异(P>0.05)。结论创伤性急性肺损伤患者早期HMGB1即开始明显升高,而血必净注射液治疗后可显著降低其外周血HMGB1水平及改善缺氧状态,具有一定治疗价值。Objective To approach effect of Xuebijing injection on the serum high mobility group box-1 protein （HMGB1） level of patients after traumatic acute lung injury. Methods A total of 50 patients with traumatic acute lung injury were randomly divided into two groups： Xuebijing injection treated group and control croup, who received xuebijing and the routine therapy. The serum HMGB1 were determined in the control croup, Xuebijing injection treated group and 10 healthy persons by enzyme linked immunosorbent assay （ELISA） before Xuebijing injection treatment and at 7 day after xuebijing treatment. The APACHEII scores, pH value, oxygenation index, the incidence rate of ARDS and the death rate were evaluated, respectively. Results Compared with the healthy persons group, the serum I-IMGBI levels in Xuebijing injection treated group and control group within 24 h after traumatic acute lung injury were notably raised. At 7 days after Xuebijing injection treatment, the serum HMGB1 level in Xuebijing injection treated group decreased significantly compared with the control group （P〈O.05）. The amelioration of pH value and oxy genation index in Xuebijing injection treated group were superior to those in the control group （P〈0.05）. However, there were no distinct with the incidence rate of ARDS and the death rate in two groups （P〉0.05）. Conclusion Xuebi jing injection treatment can obviously decrease the serum HMGB1 level of patients after traumatic acute lung injury and improve the statement of oxygen deficiency.

关 键 词：血必净注射液 创伤性急性肺损伤 急性呼吸窘迫综合症 高迁移率族蛋白B1 

分 类 号：R563[医药卫生—呼吸系统]