不同剂量阿托伐他汀治疗不稳定型心绞痛的临床观察  

Clinical observation of different doses of atorvastatin for unstable angina

作　　者：李靖 谭梅娟[2] 

机构地区：[1]长沙市第一医院,长沙410005 [2]湖南省第二人民医院,长沙410007

出　　处：《中国当代医药》2013年第26期68-69,共2页China Modern Medicine

摘　　要：目的探讨不同剂量阿托伐他汀治疗不稳定型心绞痛(UA)的临床效果。方法将76例UA患者随机分为A组(n=38)和B组(n=38),均给予常规药物治疗,A组每晚口服阿托伐他汀20 mg,B组每晚口服阿托伐他汀40 mg,两组均治疗6个月。观察治疗前后两组的血脂水平、高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及心绞痛发作情况。结果治疗后两组患者的心绞痛症状均明显改善,B组总有效率高于A组(84.21%vs60.53%)。两组治疗前血脂水平、hs-CRP、Hcy水平比较差异无统计学意义(P>0.05),治疗6个月后除高密度脂蛋白胆固醇(HDL-C)呈升高趋势外,三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP、Hcy水平较治疗前明显下降(P<0.05),且治疗后B组较A组降低更明显(P<0.05)。结论在常规治疗基础上不同剂量的阿托伐他汀治疗UA有效,且呈剂量-效应关系。Objective To investigate the clinical effect of different doses of atorvastatin in the treatment of patients with unstable angina （UA）.Methods 76 patients with UA were randomly assigned into group A （n=38） and group B （n= 38）,all received conventional medications,the patients in group A were also treated by oral atorvastatin at the dose of 20 mg every night for 6 months,the patients in group B at the dose of 40 mg every night for 6 months.The episodes of angina,the serum lipid,high-sensitivity C-reactive protein （hs-CRP）,and homocysteine （Hcy） levels before and after the treatment were observed.Results The angina symptoms of patients in both groups were significantly improved,the over- all effective rate of group B （84.21%） was higher than that of group A （60.53%）.The differences of serum lipid,hs-CRP, and Hcy levels in both groups before treatment were not statistically significant （P〉0.05）.Six months after treatment,ex- cept the level of high density lipoprotein cholesterol （HDL-C） showed a trend of elevation,the levels of triglycerides （TG）,total cholesterol （TC）,low density lipoprotein cholesterol （LDL-C）,hs-CRP,and Hcy in both groups were signifi- cantly declined （P〈0.05） compared with those before treatment;the declines in group B after treatment were more obvi- ous than those in group A （P〈0.05）.Conclusion For UA,different dose of atorvastatin is effective with dose-effect rela- tionship,on the base of conventional treatment.

关 键 词：不稳定型心绞痛 阿托伐他汀 高敏C反应蛋白 同型半胱氨酸 血脂 

分 类 号：R972.3[医药卫生—药品]