强化肠内营养对艾滋病患儿营养状况及免疫功能的影响  

The influence of the enhanced enteral nutrition on nutritional status and immune function in children with HIV/AIDS

作　　者：袁双凤[1] 汤庆娅[2] 马淑焕[1] 时艳丽[1] 陈爱民[1] 马海秀 孙亚娟[1] 邵彩红[1] 孙燕[1] 

机构地区：[1]郑州市第六人民医院营养科,河南省郑州450052 [2]上海交通大学医学院附属新华医院临床营养科

出　　处：《中国基层医药》2013年第20期3041-3044,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：世界健康基金会资助项目（AFINS-HOPE-2012-11）

摘　　要：目的 观察谷氨酰胺（Gln）强化的肠内营养干预对艾滋病患儿营养状况和T淋巴细胞免疫功能的影响.方法 将符合纳入标准的60例艾滋病患儿用随机数字表随机纳入观察组（Gln强化组30例）与对照组（常规型肠内营养组30例）.干预前和干预第28天分别检测两组患儿营养相关指标、细胞免疫指标及血清Gln浓度变化.结果 干预第28天观察组患儿的外固血总淋巴细胞计数（TLC）[（2.81 ±0.25）×109/L比（2.53±0.24）×109/L]、血清Gln水平[（7.2±2.1） μmol/L比（5.5±1.2） μmol/L]较对照组升高明显（P＜0.05）；观察组血清白蛋白（ALB）[（40.5±3.1）g/L比（38.6±2.1）g/L]、CD4＋百分比[（39.0±7.5）％比（35.3±9.9）％]、CD;/CD;比值[（1.6±0.8）比（1.2±0.6）]明显高于对照组（P＜0.01）；观察组胃肠道并发症的发生率也较对照组低（16.7％比40.0％,P＜0.01）.结论 强化肠内营养干预能改善艾滋病患儿营养状况,提高其T淋巴细胞免疫水平,降低胃肠道并发症发生率,值得临床应用推广.Objective To investigate the effect of enhanced glutamine（Gln） enteral nutrition intervention on the nutrition status and T lymphocytes-mediated immune function in children with HIV/AIDS. Methods According to the inclusion criteria,60 children with AIDS were randomly divided into observation group （ Gin improved group 30 cases） and control group （conventional enteral nutrition group 30 cases）. Before intervention and 28 days after intervention, the nutrition related index,index of cellular immunity and serum Gln changes were detected in two groups. Results In the observation group 28 days after intervention, the TLC and serum level of Gln was （2.81 ± 0.25）× 109/L, （7.2±2.1 ） μmol/L,which were significantly higher than those in the control group （2.53±0.24）× I09/L, （5.5 ± 1.2） μmol/L （ P 〈 0.05 ）. In observation group, ALB was （40.5±3.1 ） g/L, the percentage of CD4^ was （39. 0 ± 7.5） %, CD4^＋CDS＋ratio was （ 1.6±0.8 ）, which were significantly higher than those in the control group （38.6 ±2.1 ）g/L, （35.3±9.9） %, （ 1.2±0.6） （P 〈0. 01 ）. Observation group had lower incidence rate of gastrointestinal complications （ 16. 7% vs 40.0%, P 〈 0. O1 ）. Conclusion Enhanced enteral nutrition intervention can improve nutritional status in children with HIV/AIDS, raise the level of T lymphocyte immunity, reduce the incidence of gastrointestinal complications, which was worthy of clinical promotion.

关 键 词：获得性免疫缺陷综合征 肠道营养 谷氨酰胺 T淋巴细胞 儿童 

分 类 号：R725.1[医药卫生—儿科]