补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍30例临床研究  

Clinical Research on Efficacy of Bushen Huoxue Kaiqiao Prescription in the Treatment of 30 Diabetes-induced Vascular Mild Cognitive Impairment Cases

作　　者：金硕果[1] 梁静涛[1] 杨旭红[1] 赵欢[2] 史敏[2] 陈卫银[1] 孙鸿辉[1] 冉宁晶[1] 牟歌童[1] 陈寒冰[1] 杨东东[1] 

机构地区：[1]成都中医药大学附属医院,成都610075 [2]成都中医药大学临床医学院,成都610072

出　　处：《世界科学技术-中医药现代化》2013年第5期1051-1055,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：四川省人力资源和社会保障厅川财社[2011]183号糖尿病及并发症研究(CSZYJ2011016):补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍二级预防临床疗效研究;负责人:杨东东

摘　　要：目的:观察补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍的临床疗效。方法:将30例糖尿病所致血管性轻度认知功能障碍的患者随机分为治疗组(15例)和对照组(15例),治疗组予以补肾活血开窍方(肉苁蓉10 g、石菖蒲5 g、三七2.5 g)免煎制剂治疗,每天3次,同时服用尼莫地平每次30 mg、一日3次,对照组服用尼莫地平每次30 mg、一日3次,上述治疗持续6个月。治疗前后采用临床痴呆评定量表(CDR)、日常生活能力量表(ADL)、蒙特利尔认知评估北京版(MoCA)及中医症候评分进行评估。结果:治疗后2组均有进步率,治疗组86.70%,对照组33.33%,治疗组总有效率优于对照组(P<0.05)。2组患者中MoCa量表和ADL量表及中医症候评分与同组治疗前比较,差异均有统计学意义(P<0.05),治疗组治疗后优于对照组,2组比较差异有统计学意义(P<0.05)。2组不良事件发生率比较经χ2检验无统计学意义。结论:补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍临床疗效优于尼莫地平,在改善日常生活能力、认知功能、痴呆程度及中医症候评分方面均优于尼莫地平;不良事件发生率与尼莫地平相当。This study was aimed to observe clinical efficacy of Bushen Huoxue Kaiqiao （BSHXKQ） treatment of diabetes-induced vascular mild cognitive impairment. A total of 30 cases of diabetes-induced vascular mild cognitive impairment were randomly divided into the treatment group （15 cases） and the control group （15 cas- es）. The treatment group received free-fried BSHXKQ prescription （Cistanche 10 g, Shichangpu 5 g, Sanqi 2.5 g） for treatment 3 times a day, and in combination of 30 mg of nimodipine, 3 times a day. In the con- trol group, 30 mg of nimodipine was orally administrated 3 times a day. The treatment was continued for 6 months. Clinical Dementia Rating （CDR）, Activity of Daily Living Scale （ADL）, Montreal Cognitive Assessment Beijing Edition （MoCA） and TCM Syndrome Score were used in the evaluation before and after the treatment. The results showed that the rate of progress was in both groups after treatment. In the treatment group, the rate was 86.70%, and in the control group the rate was 33.33%. The total effective rate in the treatment group was superior to the control group （P 〈 0.05）. There were statistical significances in the MoCa Scale, ADL Scale and TCM Syndrome Score before and after treatment in each group （P 〈 0.05）. The treatment ef- fect in the treatment group was superior to the control group （P 〈 0.05）. There was no statistical significance in the incidence of adverse events the treatment of diabetes-induced activities of daily living, cognitive in both groups. It was concluded that the effect of BSHXKQ prescription in vascular mild cognitive impairment was superior to nimodipine in improving function, degree of dementia and TCM syndrome score. There was no differ- ence in the incidence of adverse events compared nimodipine.

关 键 词：补肾活血开窍方 糖尿病所致血管性轻度认知功能障碍 尼莫地平 临床研究 

分 类 号：R259[医药卫生—中西医结合]