虎眼万年青提取物抗肿瘤和镇痛抗炎作用研究  

Antitumor,analgesic,and anti-inflammatory effects of Ornithogalum caudatum extracts

作　　者：于艳辉 高陆 石菊 王莲萍 孙佳明[3] 许艳茹 白冰 

机构地区：[1]吉林修正药业新药开发有限公司,吉林长春130012 [2]吉林省现代中药工程研究中心有限公司,吉林长春130012 [3]长春中医药大学中医药与生物工程研发中心,吉林长春130117

出　　处：《中草药》2013年第16期2282-2284,共3页Chinese Traditional and Herbal Drugs

基　　金：吉林省中医药局项目(pt091)

摘　　要：目的观察虎眼万年青提取物抗肿瘤和镇痛、抗炎等作用。方法制备肿瘤细胞MFC、HepG-2、S180荷瘤小鼠模型,观察虎眼万年青提取物的抑瘤率;采用小鼠醋酸扭体实验观察虎眼万年青提取物的镇痛作用;采用二甲苯致小鼠耳廓肿胀实验观察虎眼万年青提取物的抗炎作用。结果虎眼万年青提取物剂量分别为5.0、2.5 g/kg能有效抑制小鼠实体瘤的生长,且有一定的剂量相关性(P<0.05、0.001);显著抑制醋酸致小鼠扭体反应,与模型组相比有显著差异(P<0.05、0.001);对二甲苯致小鼠耳廓肿胀有抑制作用,与模型组相比也有显著差异(P<0.05、0.01)。结论虎眼万年青提取物具有一定的抗肿瘤、镇痛、抗炎作用,具有良好的开发前景。Objective To investigate the antitumor, analgesic, and anti-inflammatory effects of Ornithogalum caudatum extract （OCE）. Methods The MFC, HepG-2, and S180 tumor-bearing mice models were established, and the tumor inhibitory rate of OCE was calculated; The analgesic effect of OCE was observed by acetic acid writhing test of mice; The anti-inflammatory effect of OCE was observed in xylene-induced ear edema model of mice. Results OCE （5.0 and 2.5 g/kg） could effectively inhibit the growth of solid tumors in tumor-bearing mice in a dose-dependent manner （P 〈 0.05, 0.001）; Compared with the model group, OCE （5.0 and 2.5 g/kg） could significantly inhibit the writhing response （P 〈 0.05, 0.001） and xylene-induced ear edama （P 〈 0.05, 0.01）. Conclusion OCE has certain antitumor, analgesic, and anti-inflammatory effects, suggesting they may be worth further investigation.

关 键 词：虎眼万年青提取物 抗肿瘤 抗炎 镇痛 扭体反应 

分 类 号：R282.710.5[医药卫生—中药学]