复方西羚解毒丸的定性定量方法研究  

Qualitative and quantitative study of compound Xiling Jiedu pills

作　　者：胡言光[1] 王玉团[2] 禹晓凤 时海燕[4] 

机构地区：[1]河北农业大学农学院,河北保定071001 [2]山东省食品药品检验所,济南250101 [3]山东鲁越生物制品有限公司,济南250100 [4]山东省千佛山医院药学部,济南250014

出　　处：《中南药学》2013年第8期619-621,共3页Central South Pharmacy

摘　　要：目的提高复方西羚解毒丸的质量标准。方法采用显微鉴别和薄层色谱(TLC)法对处方中多味药进行鉴别研究,采用HPLC法测定该药中牛蒡苷的含量。结果建立了金银花、荆芥穗、淡竹叶和羚羊角4味药的显微鉴别方法和冰片、薄荷脑、甘草和桔梗等4味药的薄层鉴别方法,牛蒡苷在0.047～0.470μg与峰面积呈良好线性关系(r=0.999 9),平均回收率为99.0%(RSD=0.77%)。结论该方法简便、准确、可靠,可更好地控制复方西羚解毒丸的质量。Objective To establish an identification method for compound Xiling Jiedu pills.Methods The microscopic identification and TLC were used.The content of arctiin in the prescription was determined by HPLC.Results The microscopic identification of Flos Lonicerae,Herba Schizonepetae,Herba Lophatheri and Cornu Saigae Tataricae and the TLC identification of Borneol,Menthol,Radix Glycyrrhizae and Platycodon grandiflorus in the prescription were established.There was a good linearity for imperatorin at 0.047-0.470 μg（r = 0.999 9）.The average recovery was 99.0%（RSD = 0.77%）.Conclusion This method is accurate,reliable and simple,and it can be better control the quality of compound Xiling Jiedu pills.

关 键 词：复方西羚解毒丸 显微鉴别 薄层色谱 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学] R931.5[医药卫生—药学]