淋球菌流行株对抗生素敏感性的研究  

Study on Antibiotic Susceptibility of Neisseria Gonorrhoeae Epidemic Strains

作　　者：李国明[1] 陈群[1] 王胜春[1] 吴志华[2] 

机构地区：[1]广东医学院生物学教研室,广东广州524023 [2]广东医学院附属医院皮肤科

出　　处：《中国皮肤性病学杂志》2000年第5期321-322,328,共3页The Chinese Journal of Dermatovenereology

基　　金：广东省卫生厅"五个一工程"资助!(960 1 )

摘　　要：目的　了解淋球菌流行株对抗生素的敏感性。方法　对 1998年～ 1999年间广东省湛江地区分离出的 98株淋球菌流行株 ,在系统鉴定的基础上 ,进行了抗生素敏感性的测定 ,以琼脂稀释法测定了青霉素、四环素、壮观霉素、头孢三嗪和环丙沙星的最小抑菌浓度 (MIC) ,并根据CDC标准判定敏感、中度敏感及耐药。结果　青霉素、四环素、壮观霉素、头孢三嗪及环丙沙星耐药率分别为 2 3 .91%、49.45 %、11.11%、16 .48%和 5 9.34%。结论　广东湛江地区目前流行的淋球菌菌株耐药状况十分严重 ,尤以环丙沙星为甚 ,临床常用的头孢三嗪。Objective To determine the antibiotic susceptibilities of Neisseria gonorrhoeae epidemic strains.Methods 98 gonococcal isolates obtained from 1998 through 1999 in Zhanjiang(Guang dong) were tested for their antibiotic susceptibilities based on the systemic identification.The minimum inhibitory concentrations(MIC) of penicillin,tetracyclin,spectinomycin,ceftriaxone and ciprofloxacin were determined by agar dilution method.And then defined the sensitivities of all these isolates using the CDC criteria.Results The percentage of gonococci resistances to penicillin,tetracyclin,spectinomycin,ceftriaxone and ciprofloxacin were 23.91%,49.45%,11.11%,16.48% and 59.34%,respectively.Conclusion The study showed that the resistant strains of contemporary gonococi in Zhanjiang were severe,especially the ciprofloxacin resistance.At the same time,we should pay more attention to the ceftriaxone and spectinomycin resistant gonococci.

关 键 词：奈瑟淋球菌 琼脂稀释法 抗生素敏感性 

分 类 号：R978.1[医药卫生—药品]