糖尿病性阴茎勃起功能障碍大鼠模型球海绵体肌和坐骨耻骨肌重量及显微结构的研究  

The weight and structure of bulbocavernous and ischiocavernous muscles in erectile dysfunction rats with diabetes mellitus

作　　者：王为服[1] 张元芳[2] 丁强[2] 徐一甄[2] 

机构地区：[1]海南省人民医院泌尿外科,海口570311 [2]上海医科大学华山医院

出　　处：《中国男科学杂志》2000年第3期152-155,共4页Chinese Journal of Andrology

摘　　要：SD大鼠注射链脲佐菌素制造糖尿病 (DM )动物模型后 ,注射阿朴吗啡观察 6周、8周及 1 2周大鼠阴茎勃起情况 ,筛选DM性阴茎勃起功能障碍 (ED)大鼠模型 ,研究其球海绵体肌及坐骨耻骨肌重量及显微结构的改变 ,并测定其血清睾酮浓度 ,以探讨DM性ED的发病机理。结果 :DM性ED大鼠模型球海绵体肌和坐骨耻骨肌重量及血清睾酮浓度显著降低 ;显微结构发生明显病理性改变 ,且上述变化与DM病程密切相关。提示DM严重影响阴茎勃起功能 。To research the mechanisms of erectile dysfunction(ED) with diabetes mellitus(DM),Sprague Dewley rats were injected intraperitoneally with streptozotocin (STZ) to make experimental models of DM.Injected with apomorphine,penile erections were observed and noted on the 6 th,8 th and 12 th week from the 4 th day of injecting STZ and experimental models of ED with DM were selected.The weight of bulbocavernous and ischiocavernous muscles and the concentration of testosterone in ED rats with DM decreased significantly and the sigificant pathological changes much related to the duration of DM were observed in the structrure of bulbocavernous and ischiocavernous muscles.The result indicates the function of penile erection is affected seriously by DM,and the decreasing in weight and the pathological changes in structrure of bulbocavernous and ischiocavernous muscles may be one of the most important mechanisms.

关 键 词：糖尿病 阴茎勃起障碍 球海绵体肌 坐骨耻骨肌 

分 类 号：R587.2[医药卫生—内分泌] R697.140.2[医药卫生—内科学]