氟砷联合染毒对大鼠子代大脑氧化性损伤的研究  

Effects of the fluoride arsenic combination on the oxidative damage of brain of rat's offspring

作　　者：张晨[1] 刘继文[1] 凌冰[1] 谢瑶云[1] 宋旭红[1] 王国荃[1] 

机构地区：[1]新疆医科大学公共卫生学院,乌鲁木齐830054

出　　处：《卫生毒理学杂志》2000年第3期156-159,共4页Journal of Health Toxicology

基　　金：国家自然科学基金资助!(39560075)

摘　　要：【目的】　揭示氟砷共存时对子代健康的影响。【方法】　采用两代一窝繁殖实验的方法 ,测定Wistar大鼠暴露于氟砷后其子代大脑中氟砷蓄积情况、脂质过氧化水平。【结果】　随着暴露剂量的增加 ,大脑氟砷含量显著增加 ,SOD和GSH -Px活性随之降低 ,而LPO含量却逐渐增加 ,同代不同剂量组间比较 ,差异均有非常显著意义 (P <0 0 1) ;并出现明显的病理性变化 ;停止氟砷暴露 8周后 ,大脑氟砷含量显著降低 ,酶的活性有所恢复 ,而LPO含量明显减少。Objective To explain the effects of the fluoride arsenic combination on the health of offspring. Methods The levels of fluoride and arsenic,and lipid peroxides were determined in offspring brain of rats exposed to fluoride\|arsenic,usiug the methods of two generations one nest reproductive test. Results The contents of fluoride and arsenic in brain of offspring increased,while activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) in brain of offspring decreased.In contract,the concentrations of lipid peroxides (LPO) increased.The obviously pathological changes occurred in brain.After stopping the exposure for 8 weeks,the concentrations of fluoride and arsenic in brain were decreased distinctly,the activities of SOD and GSH Px were increased, the concentrations of LPO were decreased. Conclusion Fluoride arsenic combination could cause the oxidative damage of brain of the rat's offspring.

关 键 词：氟砷联合作用 大脑 氧化性损伤 子代 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]