夏季低空飞行对飞行人员血浆SOD及红细胞膜总抗氧化能力的影响  

Effect of Combined Stress on Plasma CuZn-SOD and Erythrocyte Membrane T AOC in Pilots during Low Altitude Flight in Summer.

作　　者：秦世贞[1] 俞启福[1] 马贵喜[1] 周峥[1] 郝唯蔚[1] 李鸣皋[1] 

机构地区：[1]海军总医院,北京100037

出　　处：《航天医学与医学工程》2000年第3期200-203,共4页Space Medicine & Medical Engineering

摘　　要：目的探讨夏季低空飞行中座舱复合因素对飞行人员血浆CuZn SOD及红细胞膜总抗氧化能力(T AOC)的影响。方法 2 4名轰六飞行员为实验组 ,2 1名普通地面人员为对照组。作多靶场轰炸飞行 ,飞行高度 80 0～ 1 2 0 0m ,舱内温度 45～ 53℃ ,噪声 97～ 1 2 2dB(A) ,飞行时间 3.0h ,于飞行前 ( 6:0 0 )、飞行后即刻 ( 1 2 :0 0 )及 8h( 2 0 :0 0 )采血。对照组实行日常室内作业 ( 2 7℃ ) ,同时采血。分别用放免法及比色法测定血浆CuZn SOD及红细胞膜T AOC。结果实验组飞行前血浆CuZn SOD明显高于同一时间对照组 ;飞行后即刻明显低于飞行前及飞行后 8h。飞行后即刻红细胞膜T AOC明显高于同一时间对照组。结论夏季低空飞行中座舱复合因素使机体血液中超氧阴离子自由基增加 ,飞行后即刻血浆CuZn SOD水平下降及红细胞膜T AOC水平较普通人群增高 ,这是机体对抗增多的超氧阴离子自由基的表现。Objective To study the effect of combined stress on plasma CuZn SOD and erythrocyte membrane total antioxidant capacity (T AOC) in pilots during low altitude flight in summer.Method Twenty four pilots performing bombing for 3 h (45～53℃, 122～97 dB in the cabin, 800～1200 m altitude flight) served as the subjects. Twenty one ground personnel served as control (27℃ in the room). Blood samples were taken from the two groups before flying (6:00),immediately (12:00) and 8 h (20:00) after flying. CuZn SOD and T AOC were determined with radioimmunoassay and colorimetry respectively.Result Plasma CuZn SOD at above times were 424.70±284.10、127.80±56.23 and 248.83±160.40 ng/ml respectively in pilots and 142.90±75.63、174.22±104.97 and 262.95±129.42 ng/ml respectively in the control group. Plasma CuZn SOD at 6:00 in pilots was higher than that in control group at the same time (P< 0.01 ),and the level immediately after flying as lower than those before and 8 h after flying (P<0.01,P<0.05,respectively). The erythrocyte membrane T AOC at the above times were 1.837± 0.745 ,1.902± 0.613 and 2.185±0.780 U/mg,respectively,in pilots, and 1.834±0.713,1.395±0.544 and 2.017± 0.427 U/mg,respectively,in control group.T AOC at 12:00 in pilots was higher than that in control group at the same time (P<0.05). Conclusion Exposure of pilots to combined stress during low altitude flight in summer may increase free radicals in blood, and it may be an expression of strengthening antioxidant of the body by decrease of plasma CuZn SOD and increase of erythrocyte membrane T AOC immediately after flying.

关 键 词：飞行员 低空飞行 血浆 红细胞膜 总抗氧化能力 

分 类 号：R852.51[医药卫生—航空、航天与航海医学] R852.24[医药卫生—临床医学]