MMP-9及TIMP-1在非小细胞肺癌中的表达及意义  

Expression of MMP - 9 and TIMP - 1 in NSCLC and adjacent tissues and its clinical significance

作　　者：宋仕茂[1] 何晓文 

机构地区：[1]湖北医药学院附属太和医院肿瘤科,湖北十堰442000 [2]湖北省人民医院放疗科,湖北武汉430060

出　　处：《现代肿瘤医学》2013年第9期1978-1981,共4页Journal of Modern Oncology

基　　金：湖北科技攻关计划资助项目(编号:2006AA402C51)

摘　　要：目的:研究组织基质金属蛋白酶MMP-9及其抑制剂-1(TIMP-1)在非小细胞肺癌组织中的表达及意义。方法:通过免疫组织化学方法检测非小细胞肺癌组织和癌周组织中MMP-9和TIMP-1的表达,并分析其表达与肺癌临床病理特征的关系。结果:MMP-9、TIMP-1在肺癌组织中的阳性表达率明显高于癌旁正常组织(P<0.05),表达强度与肿瘤分化程度、临床分期、淋巴结转移密切相关(P<0.05)。结论:检测非小细胞肺癌组织中MMP-9及TIMP-1的表达对判断肿瘤的恶性程度和预后评估有一定的意义,为临床诊断和治疗提供依据。Objective：To study expression of MMP-9 and TIMP-1 in non small cell lung cancer （NSCLC） and adjacent tissues and its clinical significance.Methods：MMP-9 and TIMP-1 expression in NSCLC and adjacent-tissue was detected by immunohistochemical analysis to analyze the relationship between the expression and pathophysiological features in patients with NSCLC.Results：The positive rate of MMP-9 and TIMP-1 expression in lung cancer tissues was obviously higher than that in normal tissues （P ＜ 0.05）.The strength of expression was closely related to differentiation of carcinomas,clinical stages,and lymph node metastasis （P ＜ 0.05）.Conclusion：To detect MMP-9 and TIMP-1 expression in NSCLC might be helpful to evaluate the tumor＇s degree of malignance and prognosis and as an evidence for clinical diagnosis and treatment.

关 键 词：非小细胞肺癌 基质金属蛋白酶9 基质金属蛋白酶抑制剂1 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]