低能量体外冲击波治疗的临床应用进展  

Progress of low-energy shockwave therapy in clinical application

作　　者：辛钟成[1] 刘京[1] 王林[1] 李辉喜[1] 

机构地区：[1]北京大学第一医院男科中心,北京大学泌尿外科研究所,国家泌尿,男性生殖系肿瘤研究中心

出　　处：《北京大学学报（医学版）》2013年第4期657-660,共4页Journal of Peking University:Health Sciences

摘　　要：冲击波（shockwave,SW）也称＂激波＂,是一种双相高能量声波,频率为16～20 MHz,它区别于普通意义上的声波,是一种不连续峰在介质中的传播,当它在三维空间中迅速传播时,伴随着介质给它的压力突然上升至其最大压力,随后高峰压力在10μs内迅速下降。冲击波发生过程中能引起介质的特性（如压力、温度、SUMMARY A shock wave is a transient pressure disturbance that propagates rapidly in three-dimensional space.It is associated with a sudden rise from ambient pressure to its maximum pressure.Shock wave therapy in urology is primarily used to disintegrate urolithiasis.Recently,low-energy shock wave therapy（LESWT）,which is a novel convenient and cost-effective therapeutic modality,is extended to treat other pathological conditions including coronary heart disease,musculoskeletal disorders and erectile dysfunction.However,the exact therapeutic mechanisms and clinical safety and efficacy of LESWT remain to be investigated.Based on the results of previous studies,it is suggested that LESWT could regulate angiogenesis-related growth factors expression including endothelial nitric oxide synthase（eNOS）,vessel endothelial growth factor（VEGF） and proliferating cell nuclear antigen（PCNA）,which might induce the ingrowth of neovascularization that improves blood supply and increases cell proliferation and eventual tissue regeneration for restore pathological changes.The further studies on cellular and molecular biological changes by LESWT for clarification its mechanism and clinical safety and efficacy studies are recommended.

关 键 词：冲击波 低能量冲击波治疗 机制 疗效 

分 类 号：R692.4[医药卫生—泌尿科学]