不同类型肥胖对原发性高血压患者动脉僵硬度的影响  

Effect of Different Obese Type on Arterial Stiffness in Essential Hypertension

作　　者：宋洪斌[1,2] 刘振东[1] 路方红[1] 刁玉涛[1] 张华[1] 赵颖馨[1] 孙尚文[1] 齐在文[1,2] 

机构地区：[1]山东省医学科学院基础医学研究所心脑血管病防治研究中心 [2]济南大学山东省医学科学院医学与生命科学学院,山东省济南市250062

出　　处：《中国动脉硬化杂志》2013年第8期737-740,共4页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金项目(ZR2011HQ053;ZR2009CL029)

摘　　要：目的探讨不同类型肥胖对原发性高血压患者动脉僵硬度的影响。方法选择原发性高血压患者776例,根据体质指数(BMI)和腰围将受试者分为4组:正常BMI+正常腰围组(正常组,n=194)、正常BMI+腰围增高组(单纯腰围增高组,n=195)、BMI增高+正常腰围组(单纯BMI增高组,n=196)及BMI增高+腰围增高组(BMI和腰围增高组,n=191)。测定所有受试者肱踝脉搏波传导速度和踝臂指数;根据受试者的血脂情况,计算动脉硬化指数。结果 BMI和腰围增高组受试者的肱踝脉搏波传导速度(2120±263 mm/s)和动脉硬化指数(3.35±0.87)明显高于正常组(P<0.01)及单纯腰围增高组和单纯BMI增高组(P<0.05)。BMI和腰围增高组受试者的踝臂指数(0.72±0.15)明显低于正常组(P<0.01)及单纯腰围增高组和单纯BMI增高组(P<0.05)。单纯BMI增高组受试者的踝臂指数及动脉硬化指数与单纯腰围增高组无统计学差异(P>0.05)。析因分析结果显示,BMI和腰围增高对动脉僵硬度的影响均显著,且二者存在协同效应。结论腹型肥胖的原发性高血压患者动脉弹性受损程度严重,BMI和腰围增高对动脉弹性功能受损有交互协同作用。Aim To investigate the effect of different obese type on arterial stiffness in essential hypertension Methods The basic information was collected in a total of 776 essential hypertensive patients. According to body mass index （BMI） and waist circumference （WC） level, all patients were divided into four groups, namely, normal BMI and normal waist circumference group （ I group, n = 194）, normal BMI and elevated waist circumference group （ I group, n = 195）, excessive BMI and normal waist circumference group （ m group, n--196）, excessive BMI and elevated waist circumference group （ IVgroup, n = 191 ）. Brachial ankle pulse wave velocity （BaPWV） and ankle-brachial blood pres- sure index （ABI） were observed in all patients. Arterial stiffness index （AI） was calculated using the blood lipid of all hypertension patients. Results BaPWV （2120 _＋ 263 mm/s） and AI （3.35 ＋ 0. 87 ） in IV group were significantly higher than I group （P 〈0. 01 ）, II group and m group （P 〈0. 05）. ABI （0.72 _0. 15） in IV group were significantly lower than I group （ P 〈 O. 01 ） , II group and m group （ P 〈 0. 05 ）. There were no statistical differences between lI group and HI group in ABI and AI （ P 〉 0. 05 ）. Results of 2 x 2 factorial analysis showed that there was a distinctive and synergistic effect between excessive BMI and elevated waist circumference on arterial stiffness. Conclusion Arterial elasticity function was aggravatedly damaged in essential hypertension in patients with abdominal obesity. Excessive BMI and elevated waist circumference had interaction and synergistic effect on the damage of arterial elasticity function.

关 键 词：腹型肥胖 动脉僵硬度 高血压 

分 类 号：R5[医药卫生—内科学]