高危后循环短暂性脑缺血发作患者CD4^+ CD25^+调节性T细胞检测及意义  

Significance of Change of CD4^+ CD25^+ Regulatory T Cells in Patients with High-risk Transient Ischemic Attack in Posterior Circulation

作　　者：杨汀[1] 樊光辉[2] 刁波[3] 

机构地区：[1]广州军区武汉总医院心血管内科,湖北省武汉市430070 [2]广州军区武汉总医院院长办公室,湖北省武汉市430070 [3]广州军区武汉总医院神经外科实验室,湖北省武汉市430070

出　　处：《中国动脉硬化杂志》2013年第8期755-757,共3页Chinese Journal of Arteriosclerosis

基　　金：2010年度军队中医药科研专项课题(10ZYZ117)

摘　　要：目的探讨高危后循环短暂性脑缺血发作患者外周血CD4+CD25+调节性T细胞(Treg)水平及意义。方法采用流式细胞分析法,检测21例高危后循环短暂性脑缺血发作患者、19例眩晕综合征患者及20例健康成人外周血Treg占CD4+T细胞比例。结果高危后循环短暂性脑缺血发作组外周血Treg/CD4+T细胞比例(5.66%±1.91%)显著低于眩晕综合征组(9.18%±2.26%)和健康成人组(9.21%±2.71%)。结论高危后循环短暂性脑缺血发作患者外周血Treg比例下降。Treg比例降低可能破坏了外周自身免疫耐受并参与了动脉粥样硬化的发生发展,可能是高危后循环短暂性脑缺血发作的发病机制之一。Aim To explore the significance of the change of CD4±CD25± regulatory T cells （Treg） in patients with high-risk transient ischemic attack （TIA） in posterior circulation. Methods The frequencies of Treg were detec- ted in 21 patients with high-risk TIA in posterior circulation, 19 patients with dizziness syndrome and 20 health adults by flow cytometer. Results The frequencies of Treg were found to be significantly lower in patients with high-risk TIA in posterior circulation （5.66% ± 1.91% ） than those of dizziness syndrome （9. 18% ±2. 26% ） and health adults （9. 21% ± 2. 71% ）. Conclusions The frequencies of Treg decrease in patients with high-risk TIA in posterior circulation. The decrease of Treg may lead to the breakdown of autoimmune tolerance and participate in the progression of atherosclero- sis, which could be one of the pathogenesis of the high-risk TIA in posterior circulation.

关 键 词：短暂性脑缺血发作 CD4+CD25+调节性T细胞 自身免疫 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]