Wistar大鼠的自发性非肿瘤病变及其发生率  

Spontaneous non-neoplastic lesions of Wistar rats and their incidences

作　　者：徐艳峰[1] 侯粉霞[2] 杨慧芳[2] 

机构地区：[1]中国医学科学院医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 [2]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《中国比较医学杂志》2013年第8期44-47,共4页Chinese Journal of Comparative Medicine

摘　　要：目的了解Wistar大鼠的各种自发性非肿瘤病变及其发生率。方法慢性毒性与致癌合并试验中的对照组,采用4周龄SPF级Wistar大鼠,雌、雄性大鼠各60只,试验前观察1周,常规饲料喂饲104周后处死,进行组织病理学检查。结果分析和报告了Wistar大鼠的各种自发性非肿瘤病变及其发生率。雄性大鼠发生率高的病变主要为肾脏、心脏、肝脏和睾丸等脏器病变;雌性大鼠发生率高的病变主要为肝脏、肾上腺和肾脏等脏器病变。结论本文报告的Wistar大鼠的各种自发性非肿瘤病变及其发生率可为相关技术人员提供一些参考。Objective To understand the spontaneous non-neoplastic lesions and their incidences in rats. Methods The control group of a combined chronic toxicity and carcinogenicity test included 60 male and 60 female 4- week-old specific pathogen-free Wistar rats. The rats were acclimatized for 1 week prior to initiation of the test. The rats were fed with conventional teed for 104 weeks and then sacrificed for histopathological examination. Results Various non- neoplastic lesions of the rats and their incidences were analyzed and reported. The lesions with high incidence in male rats occurred mainly in the kidney, heart, liver and testis, and the lesions with high incidence in female rats occurred mainly in liver, adrenal gland and kidney. Conclusions The data of non-neoplastic lesions in the Wistar rats obtained in this study can provide some reference for relevant technical staffs.

关 键 词：WISTAR大鼠 慢性毒性 自发性非肿瘤病变 

分 类 号：R33[医药卫生—人体生理学]