半乳糖凝集素(Galectin)与HIV相关性研究进展  

Progress in research on the association of galectins and HIV

作　　者：傅春燕[1] 薛婧[1] 魏强[1] 

机构地区：[1]北京协和医学院比较医学中心,中国医学科学院医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021

出　　处：《中国比较医学杂志》2013年第8期52-55,共4页Chinese Journal of Comparative Medicine

基　　金：协和青年基金(2012J24);中央高校基本科研业务费专项资金(DWS201208)

摘　　要：半乳糖凝集素(galectin)是动物凝集素家族中的一员,对β-半乳糖具有特殊的亲和力,广泛存在于各种动物体内,通过与宿主细胞表面的糖蛋白结合,影响细胞黏附、细胞迁移、细胞生长和免疫反应等多种生物学功能。近来,研究者发现其与HIV之间存在着一定的相关性。Galectin家族的某些成员能够促进HIV的感染,某些成员可以调节HIV感染细胞的凋亡敏感性。本文就半乳糖凝集素与HIV之间的相关性研究进展做一综述。Galectins are a family of ^-galactosides-binding proteins. They exist extensively in various animals. Galectins have been found to modulate important biological activities of cells such as adhesion, migration, proliferation, apoptosis, signaling and immune response through binding to glycoproteins on the cell surface. Recently, galectins have been found to be associated with HIV-1 infection and apoptosis in HIV-1-infected cells. Some promote HIV-I infection and others modulate apoptosis in HIV-1 infected cells. In this article, we will review the progress in research of the association of galectins with HIV infection and apoptosis in HIV-1 infected cells.

关 键 词：半乳糖凝集素 HIV-1感染 凋亡 

分 类 号：R33[医药卫生—人体生理学]