HBeAg阴性慢性乙型肝炎和非活动期HBsAg携带状态的Pre-S1抗原阳性率研究  

Comparison of Pre-S1 antigen positive rate between HBeAg negative chronic hepatitis B patients and inactive HBsAg carriers

作　　者：马宁[1] 韩辉[1] 陈焕永[1] 李庆刚[1] 邵凤娟[1] 

机构地区：[1]哈尔滨医科大学附属第一医院老年病科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2013年第4期341-343,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目(11511214);黑龙江省青年科学技术专项资金(QC07C70)

摘　　要：目的探讨Pre-S1抗原对HBeAg阴性慢性乙型肝炎发生的诊断意义。方法选择HBeAg阴性慢性乙型肝炎病例和非活动期HBsAg携带状态病例各45例作为研究组,并以HBeAg阳性慢性乙型肝炎和免疫耐受期病例各20例分别作为其对照组。应用酶联免疫法(ELISA)测HBsAg,HBsAb,HBeAg,HBeAb,HBcAb,Pre-S1抗原,应用聚合酶链反应(PCR)检测HBV-DNA。结果 HBeAg阴性慢性乙型肝炎组与非活动期HBsAg携带状态组Pre-S1抗原阳性率有统计学差异(χ2=4.121,P=0.035)。HBeAg阴性慢性乙型肝炎组与HBeAg阳性慢性乙型肝炎组Pre-S1抗原阳性率无统计学差异(χ2=2.921,P=0.083)。非活动期HBsAg携带状态组与免疫耐受组Pre-S1抗原检测阳性率有显著性差异(χ2=6.573,P=0.009)。结论 Pre-S1抗原可作为观察非活动期HBsAg携带状态是否稳定的监测指标,如出现Pre-S1抗原阳性提示非活动期HBsAg携带状态易发展为HBeAg阴性慢性乙型肝炎。Objective To investigate the diagnostic value of Pre-S1 antigen testing in the de- velopment of HBeAg negative chronic hepatitis B. Methods Forty-five cases of HBeAg nega- tive chronic hepatitis B and 45 cases of inactive HBsAg carrier were included in experimental groups; 20 cases with HBeAg positive chronic hepatitis B and 20 cases with chronic hepatitis B virus infection in immune tolerant phase were included in control groups, respectively. HBsAg, HBsAb, HBeAg, HBeAb, HBcAb and Pre-S1 antigen were tested by ELISA; HBV-DNA was tested by PCR. Results Pre-S1 antigen positive rate in the HBeAg negative hepatitis B group was significantly higher than that in the inactive HBsAg carrier group （X2 = 4. 121, P = 0. 035）. Similar statistical significance was found when comparing the immune tolerant group with the inactive HBsAg carrier group （X2 = 6. 573, P = 0. 009）. Otherwise, There was no statistical significance in Pre-S1 antigen positive rate between HBeAg negative chronic hepatitis B group and HBeAg positive chronic hepatitis B group（x2 = 2. 921, P = 0. 083 ）. Conclusion Pre-S1 antigen can be used as a monitoring index in assessing the stability of inactive HBsAg carrier state. The inactive HBsAg carrier status with Pre-S1 antigen positive would be result in progression to HBeAg negative chronic hepatitis B.

关 键 词：乙型肝炎 慢性 HBEAG阴性 Pre—S1抗原 非活动期HBsAg携带状态 

分 类 号：R512.62[医药卫生—内科学]