中药复方对成骨细胞增殖及骨密度的影响  

Chinese herbal compound affects osteoblast proliferation and bone mineral density

作　　者：颜军礼 李蒙[2] 李瑞玉[3] 吴立萍[4] 孙艳浮 李会龙[3] 

机构地区：[1]河北省任县医院,河北省邢台市055150 [2]武警新疆总队和田地区支队卫生队,新疆维吾尔自治区和田市848011 [3]邢台医学高等专科学校第二附属医院中西医结合研究所,河北省邢台市054000 [4]河北医科大学附属邢台市人民医院检验科,河北省邢台市054031

出　　处：《中国组织工程研究》2013年第33期6055-6060,共6页Chinese Journal of Tissue Engineering Research

基　　金：河北省中医药管理局资助项目(项目编号2012068)~~

摘　　要：背景:复方中药是由多种矿物植物动物等物质组成的复方药物,在治疗骨代谢疾病方面,能通过多途径,多靶点发挥综合治疗作用。目的:研究复方中药对成骨细胞增殖及骨密度的影响,探讨复方中药对骨质疏松症的药理作用。方法:回顾性分析以往经实验研究证实的某些复方中药对骨质疏松症动物模型成骨细胞增殖分化及骨密度的影响,分析影响复方中药促进骨形成的因素,通过对成骨细胞体外培养方法进行筛选,找出促进细胞增殖分化、提高骨密度的药物适宜剂量,与化学药物结果进行对照研究。结果与结论:复方中药能够促进成骨细胞增殖分化、提高骨密度,在治疗骨质疏松症方面具有标本兼治、毒副作用小等优点,但复方中药在改善骨密度水平方面不及化学药物,并且应通过长期、大样本的临床研究,降低骨质疏松性骨折风险的干预作用。BACKGROUND： Compound Chinese medicine is a kind of compound drugs with the combination of minerals, plants and animals, which play the multi-target integrated treatment effects in the treatment of bone metabolic disease through various methods. OBJECTIVE： To research the effect of compound traditional Chinese medicine on the proliferation and bone mineral density of osteoblasts, and to explore the pharmacological effect of compound traditional Chinese medicine in the treatment of osteoporosis. METHODS： A retrospective analysis was performed to analyze the effect of some compound traditional Chinese medicines on the proliferation and bone mineral density of osteoblasts that identified in the previous studies, in order to analyze the factors of compound traditional Chinese medicines that can promote the bone formation. The appropriate dose of the drugs that can promote call proliferation and differentiation and improve the bone mineral density was screened out through the in vitro culture of osteoblasts, and then compared with the results of chemical medicines. RESULTS AND CONCLUSION： Compound traditional Chinese medicines can promote the proliferation and differentiation of osteoblasts and improve the bone mineral density, and have the advantages of full treatment andless side effect in the treatment of osteoporosis. But the effect of compound traditional Chinese medicines in improving the bone mineral density is less than the chemical drugs. The long-term and large-sample clinical studies should be performed to decrease the risk of osteoporotic fracture.

关 键 词：组织构建 组织构建学术探讨 复方中药 补肾中药 骨质疏松症 骨质量 骨密度 成骨细胞 细胞培养 含药血清 骨钙素 去势大鼠 骨生物力学 骨矿含量 省级基金 

分 类 号：R318[医药卫生—生物医学工程]