心血管医疗装置的聚合物表面构建及生物相容性  

Surface construction and biocompatibility of polymeric used for cardiovascular medical device

作　　者：陈宝林[1] 王东安[2,3] 

机构地区：[1]呼伦贝尔学院科研处,内蒙古自治区呼伦贝尔市021008 [2]浙江大学高分子科学研究所,浙江省杭州市310027 [3]Department of Pharmaceutical Sciences, University of Tennessee Health Science Center

出　　处：《中国组织工程研究》2013年第34期6183-6192,共10页Chinese Journal of Tissue Engineering Research

摘　　要：背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:考察用于心血管组织工程的新型植(介)入型聚合物材料(表面)的生物相容性、血液相容性和细胞相容性。方法:检索1967至2012年PubMed数据库及万方数据库。检索词为"biocompatibility,lood compatibility biomedical materials,biomedical polymer materials;生物相容性材料,血液相容性材料,生物医用材料,医用高分子材料"。结果与结论:深入研究了可用作生物材料的接枝共聚物表面和嵌段共聚物表面,发现表面与本体的差别将体现在从表面向本体延伸的很多层分子上,而两种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为,即表面能和分子运动性。如果考虑到对本体-表面的组成差异的理解,则还必须追加另以附加决定因素,即各组分的结晶行为。如果接枝共聚物或嵌段共聚物中所含的组分之一具有相对较高的结晶性,则另一组分将被挤榨出去,结果导致表面的分区化;结晶也阻碍分子的运动及扩散,最终共聚物两组分的不相容程度将影响本体及表面层中的相分离趋势。BACKGROUND： Biomaterials for the treatment of cardiovascular diseases must have anti-thrombotic, anti-biodegradability and anti-infective ability in the blood-contact condition. OBJECTIVE： To investigate the biocompatibility, blood compatibility and cytocompatibility of new implantable （interfered） polymer material （surface） used in cardiovascular tissue engineering. METHODS： The PubMed database and Wanfang database were retrieved for the related articles from 1967 to 2012 with the key words of ＂biocompatibility, Iood compatibility, biomedical materials, biomedical polymer materials＂. RESUTLS AND CONCLUSION： The graft copolymer surface and a block copolymer surfactant that can be used as biological materials were in-depth analyzed though analyzing the design requirements of type, application, cardiovascular medical devices and implantable soft tissue substitutes of polymeric biomaterials used for cardiovascular medicine. The results showed that the difference between the surface and noumenon will be reflected on many molecular layers that extended from the surface to the noumenon, while the two main factors of surface energy and molecular motion determined the noumenon/surface behavior including the noumenon/surface difference and surface phase separation. If the understanding of the noumenon/surface consisting difference should be taking into consideration, the other determinant should be added too, that was the crystallization behavior of each competent. If the one of the components contained in the graft copolymer surface and a block copolymer surfactant had higher crystallinity, the other components will be squeezed out; crystallization could also hindered the motion and diffusion of molecules, and eventually, the incompatibility degree of two components of copolymers will affect the phase separation tendency in the noumenon and surface layers.

关 键 词：生物材料 生物材料综述 聚合物生物材料 生物医用聚合物材料 生物相容性 血液相容性 细胞相容性 接枝共聚物表面 嵌段共聚物表面 

分 类 号：R318[医药卫生—生物医学工程]