膝骨关节炎关节镜清理后即刻与2周后注射玻璃酸钠的比较  

Sodium hyaluronate injection immediately versus 2 weeks after arthroscopic debridement for knee osteoarthritis

作　　者：姜军[1] 倪磊[1] 

机构地区：[1]北京大学人民医院骨关节科,北京市100044

出　　处：《中国组织工程研究》2013年第35期6375-6380,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:膝关节骨关节炎关节镜下清理后注射玻璃酸钠可以起到减轻术后疼痛、改善关节功能的作用,但在膝关节镜下清理术后何时注射玻璃酸钠却存在争议。目的:研究膝关节骨关节炎关节镜下清理后向膝关节腔内注射玻璃酸钠的时间,术后即刻注射和术后2周抽吸关节积液后再注射,何时注射更有利于促进术后膝关节功能康复。方法:应用前瞻性随机对照方法分析100例膝骨关节炎关节镜下清理术患者术后即刻注射和术后2周抽液后注射玻璃酸钠的临床资料,记录术前疼痛目测类比评分、Lysholm评分,术后6周疼痛目测类比评分,3个月时疼痛目测类比评分、Lysholm评分,比较两组患者术后膝关节功能近期康复的效果。结果与结论:即刻注射和2周后注射组术前疼痛目测类比评分分别为(6.52±2.38)分和(6.54±2.37)分,两组比较差异无显著性意义;Lysholm评分分别为(43.44±16.18)分和(51.12±16.30)分,即刻注射组低于2周后注射组。即刻注射组术后6周疼痛目测类比评分为(3.20±2.46)分,显著优于2周后注射组(5.10±2.68)分;即刻注射组术后3个月疼痛目测类比评分(2.72±2.70)分,Lysholm评分为(80.58±15.63)分,均显著优于2周后注射组(4.72±3.07分)、(64.96±21.68)分。说明术后即刻注射玻璃酸钠更有利于膝骨关节炎关节镜下清理术后膝关节功能的近期康复。BACKGROUND： Sodium hyaluronate injection after arthroscopic debridement of knee osteoarthritis can reduce postoperative pain and improve joint function, but there is a controversy on the time for the hyaluronate injection after arthroscopic debridement of knee osteoarthritis. OBJECTIVE： To observe the time of hyalurenate injection after arthroscopic debridement of knee osteoarthritis, and to compare recent rehabilitation effect of knee sodium hyaluronate injection for knee function after arthroscopic debridement of knee osteoarthritis between injection just after knee arthroscopy and injection 2 weeks after knee arthroscopy. METHODS： The clinical data of 100 knee osteoarthritis patients undergoing sodium hyaluronate injection immediately and 2 weeks after arthroscepic debridement were analyzed with prospective randomized controlled trial method, and the preoperative visual analog scale score, Lysholm score, 6 weeks postoperative visual analog scale score, 3 months postoperative visual analog scale score, and 3 months postoperative Lysholm score were recorded. The effects of recently rehabilitation of knee joint after surgery in two groups were compared. RESULTS AND CONCLUSION： There was no significant difference in postoperative visual analog scale score between immediate injection group （6.52±2.38） and 2 weeks postoperative injection group （6.54±2.37）. Thepreoperative Lysholm score in the immediate injection group （43.44±16.18） was lower than that in the 2 weeks postoperative injection group （51.12±16.3）. The 6 weeks postoperative visual analog scale score in the immediate injection group （3.2±2..46） was significantly higher than that in the 2 weeks postoperative injection group （5.1±2.68）. The 3 months postoperative visual analog scale score/Lysholm score in the immediate injection group （2.72±2.70）/（80.58±15.63） were significantly higher than those in the 2 weeks postoperative injection group （4.72±3.07）/（64.96±1.68）. The results indicate that sodium hy

关 键 词：骨关节植入物 骨与关节临床实践 膝骨关节炎 关节镜清理 玻璃酸钠 注射时间 康复 功能评估 疼痛目测类比评分 

分 类 号：R318[医药卫生—生物医学工程]