蓝氏贾第鞭毛虫的免疫逃避机制  

Immune evasion mechanisms of Giardia lamblia

作　　者：王洋[1] 田喜凤[1] 

机构地区：[1]河北联合大学生命科学学院,唐山063000

出　　处：《中国人兽共患病学报》2013年第9期909-913,共5页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(No.30970313);河北省青年科学基金(No.C2012401039)联合资助~~

摘　　要：蓝氏贾第鞭毛虫(Giardia lamblia,简称贾第虫)是一种世界性分布的机会性致病原虫,能够引起以腹泻为主要表现的贾第虫病,严重影响人类尤其是儿童的健康和发育。在贾第虫感染过程中,宿主的非特异性和特异性免疫系统均会产生强烈的抗贾第虫效应,但贾第虫通过抗原漂变、L-精氨酸饥饿等机制逃避和抑制宿主的免疫反应,引起宿主的长期或反复感染。本文对宿主的抗贾第虫免疫以及贾第虫的免疫逃避机制做一综述。As a world wide opportunistic protozoan parasite, Giardia lamblia can cause giardiasis in human and other mammals, which are hazardous to human health, especially to children. During the infection of Giardia lamblia, the non-spe- cific and specific immune response of host individuals would generate strong anti-Giardia effect. However, Giardia lamblia can evade or inhibit the host＇s immune response by some mechanisms including antigenic shift and arginine starvation, which results in prolonged or repeated infection. This article will review the hosts＇ anti Giardia immune and the immune evasion mechanisms of Giardia lamblia.

关 键 词：蓝氏贾第鞭毛虫 免疫逃避 抗原漂变 L-精氨酸饥饿 

分 类 号：R382[医药卫生—医学寄生虫学]