黄精地龙方对老年痴呆大鼠行为认知及脑胆碱能系统的影响  

The effect of the Rhizoma Polygonati and Earth Worm mixtures on cognitive ability and cholinergic system of Alzheimer's disease in rats

作　　者：肖移生[1] 曾元凤[2] 欧阳厚淦[1] 程昊[1] 陈乔[1] 

机构地区：[1]江西中医药大学基础医学院,南昌330004 [2]江西省人民医院,南昌330006

出　　处：《中药药理与临床》2013年第4期146-148,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：江西省卫生厅中医药科研基金项目(项目编号:2012A144)资助

摘　　要：目的：探讨黄精地龙方对老年痴呆（AD）大鼠的学习记忆、脑组织过氧化与抗氧化系统、脑内胆碱能系统功能的影响。方法：采用颈背部皮下注射1%D-半乳糖联合腹腔注射东莨菪碱复制大鼠AD模型,再用黄精地龙方浓缩提取液（2~8g/kg）灌胃AD大鼠,观察该组方对大鼠学习记忆能力、脑组织SOD、MDA、GSH-Px、Ach、ChAT、AchE等生化指标的影响。结果：2~8g/kg剂量范围内黄精地龙方能明显增强AD大鼠学习记忆能力,减少学习记忆错误次数,增加脑组织的Ach含量及ChAT、SOD、GSH-Px活性,降低MDA含量及AchE活性。结论：黄精地龙方对老年痴呆有一定治疗作用。Objective： To observe the functions of Rhizoma Polygonati and Earth Worm mixtures（RPEWM） on learning and memory abilities and brain enzymatic activites and cholinergic system of Alzheimer’s disease（AD） in rats.Methods： After making the AD models by nuchal subcutaneous injected 1% D-galactose by intraperitoneal injected scopolamine in the rats,then intragastric administrated by extractive of RPEWM at 2 ~ 8g / kg·d dose,we investigated the learning and memory abilities and detected SOD,GSH-Px,MDA,Ach,ChAT,AchE activites in brain tissues of the AD rats which medicated by RPEWM.Results： Compared with model group,RPEWM can significantly increased the learning and memory abilities and decreased the wrong behaviors of the AD rats.It also increased the activities of SOD,GSH-Px,Ach,ChAT,and decreased the amount of MDA,AchE in the brain tissues.Conclusion： RPEWM possess the function of anti-AD.

关 键 词：黄精地龙方 老年痴呆 学习记忆 胆碱能 

分 类 号：R285[医药卫生—中药学]