降钙素原诊断下呼吸道感染价值  

Value of procalcitonin to the diagnosis of lower respiratory tract infection

作　　者：樊满齐[1] 张鑫[1] 刘翱[1] 张鸿玲[1] 赵生涛[1] 周涛[1] 胡赤[1] 

机构地区：[1]成都军区昆明总医院呼吸内科,昆明650032

出　　处：《中华实用诊断与治疗杂志》2013年第9期884-885,887,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的评价降钙素原在下呼吸道感染诊断中的价值。方法下呼吸道感染患者172例,其中慢性阻塞性肺疾病急性加重期患者82例(AECOPD组)和肺炎患者90例(肺炎组),同期体检健康者54例为对照组,采用免疫色谱测定法检测3组血清降钙素原水平,采用免疫透射比浊法检测3组血清C反应蛋白水平,应用全自动血细胞分析仪行血常规检查。结果肺炎组血清降钙素原、C反应蛋白、白细胞计数及中性粒细胞百分比明显高于AECOPD组与对照组(P<0.05);降钙素原对肺炎有较好的诊断价值,最佳界值为0.35μg/L,敏感度为67.8%,特异度为85.2%,阳性预测值为88.06%,阴性预测值为59.74%。结论降钙素原对肺炎的诊断价值优于C反应蛋白和白细胞计数。Objective To evaluate the value of serum procalcitonin （PCT） to the diagnosis of lower respiratory tract infection （LRTI）. Methods A total of 172 patients with LRTI were divided into 82 patients with acute exacerbation of chronic obstructive lung disease （AECOPD） and 90 patients with pneumonia. Another 54 healthy volunteers were as controls. The PCT level was detected by using immune chromatographic assay, C-reactive protein （CRP） was detected by using immunoturbidimetry assay, and blood routine examination was performed by using automatic blood cell analyzer. Results The levels of PCT, CRP, white blood count and percentage of neutrophils were higher in pneumonia patients than those in AECOPD patients and normal controls, which showed significant differences （P〈0.05）. PCT had a good diagnostic value to pneumonia, with the optimal cut-off point of 0.35 μg/L, the sensitivity of 67.8% and the specificity of 85.2%. The positive predictive value was 88.06% and the negative predictive value was 59.74%. Conclusion PCT is superior to CRP and white blood count for diagnosing pneumonia.

关 键 词：慢性阻塞性肺疾病 急性加重 降钙素原 肺炎 

分 类 号：R56[医药卫生—呼吸系统]