The CXXC-TET bridge - mind the methylation gap!  

作　　者：Donncha S Dunican Sari Pennings Richard R Meehan 

机构地区：[1]MRC Human Genetics Unit, Institute of Genet-ics and Molecular Medicine, University of Edin-burgh, Crewe Road, Edinburgh, EH4 2XU, UK [2]Centre for Cardiovascular Science, Queen'sMedical Research Institute, Universi(y of Ed-inburgh, 47 Little France Crescent, Edinburgh,EH16 4T J, UK

出　　处：《Cell Research》2013年第8期973-974,共2页细胞研究（英文版）

摘　　要：CG-rich DNA ＂reader＂ proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differen- tiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regula- tion of Ten-Eleven-Translocation 2 （TET2） protein function.

关 键 词：甲基化 TET 蛋白质结合 差距 细胞分化 CPG序列 C结构域 结合因子 

分 类 号：Q523[生物学—生物化学] TM278[一般工业技术—材料科学与工程]