藤黄酸抗肿瘤机制的研究进展  

Progress in understanding mechanisms behind anti-tumor effects of gambogic acid

作　　者：侯毅[1] 竺平[1] 陈邑岐[2] 朱秉宜[2] 谷云飞[2] 

机构地区：[1]南京中医药大学第一临床医学院,江苏省南京市210029 [2]南京中医药大学附属医院,江苏省南京市210029

出　　处：《世界华人消化杂志》2013年第24期2412-2417,共6页World Chinese Journal of Digestology

基　　金：江苏省自然科学基金资助项目;No.BK2008457~~

摘　　要：藤黄酸是中药藤黄树脂的有效成分之一.本文查阅国内外相关文献,大量实验研究显示该药物通过不同机制发挥抗肿瘤作用,包括诱导细胞凋亡,诱导细胞周期停滞,抑制端粒酶末端转移酶活性,抑制拓扑异构酶活性,抑制血管生成,逆转肿瘤耐药,抑制通道蛋白表达等,对多种肿瘤细胞有潜在抗肿瘤活性,提示藤黄酸作为一种新型化疗药物进入临床前景广阔.本文就该药抑制肿瘤机制研究作综述,为深入研究藤黄酸提供理论依据,也为开发新的化疗药物提供思路.Gambogic acid, a major active component of gamboge resin extracted from Garcinia hanburyi tree, has potent anti-tumor activities. Based on domestic and foreign literature, we speculate that the anti-tumor activities of gambogic acid might be mediated via different mechanisms, including inducing cell apoptosis and cell cycle arrest, inhibiting the activity of telomerase or topoisomerase, reducing tumor cell invasion, adhesion and migration, and reversal of tumor multidrug resistance （MDR）. In this paper, we review the mechanisms behind the anti-tumor effects of gambogic acid, with an aim to providesome new clues to the development of anti- tumor drugs.

关 键 词：藤黄酸 抗肿瘤机制 研究进展 

分 类 号：R285.5[医药卫生—中药学]