对硝基异氰酸苯酯衍生化β-环糊精手性固定相分离β-受体阻滞剂  

Preparation of p-nitrophenylcarbamoylated β-cyclodextrin chiral stationary phase and enantioseparation of β-blockers

作　　者：李来生[1] 周仁丹[1] 程彪平[1] 聂桂珍[1] 张杨[1] 

机构地区：[1]南昌大学分析测试中心,江西南昌330047

出　　处：《南昌大学学报（理科版）》2013年第3期233-238,共6页Journal of Nanchang University(Natural Science)

基　　金：国家自然科学基金资助项目(21165012);江西省自然科学基金资助项目(2010GZH0089);江西省教育厅科技资助项目(GJJ11274)

摘　　要：通过click反应合成对硝基异氰酸苯酯衍生化β-环糊精键合SBA-15硅胶手性固定相(NPCSP),在极性有机溶剂模式下对阿替洛尔、美托洛尔、艾司洛尔3种β-受体阻滞剂类药物进行手性分离的研究。实验结果表明,在优化的色谱条件下获得了较好的分离,所制备的手性固定相具有较高的分离效率。针对β-受体阻滞剂类药物的结构特点,对相关手性分离机理进行了探讨。本方法具有简便、快捷、高效及重复性好等特点。The p-nitrophenylcarbamoylated β-cyclodextrin chiral stationary phase（NPCSP） was prepared by the click chemistry and enantioseparation of atenolol,metoprolol and esmolol was studied under the polar organic mode.It shows that the enantioseparation of them has achieved with satisfactory result under optimized chromatographic conditions and the chiral stationary phase has higher separation efficiency.The related mechanism of chiral separation is discussed based on the structural feature of β-blockers drug in this paper.This method is convenient,efficient and good repeatability.

关 键 词：高效液相色谱 β-环糊精手性固定相 手性分离 Β-受体阻滞剂 

分 类 号：O657[理学—分析化学]