血浆tHcy对评估非小细胞肺癌化疗效果及其活动状态价值的研究  

The role of tHcy expressions in evaluating the effects of chemotherapy in treating non-small cell lung cancer and tracking the tumor's activity

作　　者：鞠方鹤[1] 肖祖克[2] 王真[1] 

机构地区：[1]浙江省中医院呼吸内科,浙江杭州310006 [2]江西省人民医院呼吸内科,江西南昌330006

出　　处：《健康研究》2013年第4期280-282,共3页Health Research

摘　　要：目的探讨血浆总同型半胱氨酸(total homecysteine,tHcy)表达水平对评估晚期非小细胞肺癌(non-small celllung cancer,NSCLC)化疗效果及肿瘤活动状态的价值。方法采用前瞻性对照研究方法,分析80例晚期非小细胞肺癌化疗前后有效控制、进展、有效控制后复发时tHcy的变化,进而评价tHcy与化疗效果及肿瘤活动状态的关系。结果 80例晚期非小细胞肺癌患者化疗1～2周期后,56例得到有效控制,其tHcy由(16.75±4.83)μmol.L-1降至(10.92±3.26)μmol.L-1。在随访过程中34例复发,其tHcy由(12.57±3.02)μmol.L-1升高至(19.23±3.58)μmol.L-1。化疗无效进展者24例,其tHcy由(15.82±4.75)μmol.L-1升高至(20.32±4.50)μmol.L-1。三组差异均有统计学意义(P<0.05)。结论 tHcy对评价晚期NSCLC化疗效果及肿瘤活动状态有重要价值。Objective To develop a scientific method for evaluating the effects of chemotherapy in treating advanced non-small cell lung cancer（NSCLC） and tracking the activity of the tumor.Method ＇Prospective case-control study＇ is employed to analyze the changes of tHcy before and after the effective control,in the progress,and in the recurrence after effective control of 80 cases of advanced NSCLC,and evaluate the relationship between tHcy and the effect of chemotherapy and the activity of tumor.Results After the first or second cycle of chemotherapy,56 cases among the 80 advanced NSCLC have been effectively controlled.Their tHcy decreased from（16.75± 4.83）μmol·L-1 to（10.92±3.26）μmol·L-1.34 cases of the follow-up recurred,and their tHcy rose from（12.57±3.02）μmol·L-1 to（19.23±3.58）μmol·L-1.24 cases of chemotherapy were invalid,and their tHcy rose from（15.82±4.75）μmol·L-1 to（20.32±4.50）μmol·L-1.The differences among these three groups are statistically significant（P0.05）.Conclusion tHcy can be an efficient benchmark in evaluating the effects of the advanced NSCLC chemotherapy and the activity of the tumor.

关 键 词：非小细胞肺癌 总同型半胱氨酸 化疗 肿瘤标志物 

分 类 号：R56[医药卫生—呼吸系统]