Structure modification of fenvalerate metabolized in Trichoplusia ni cells  

作　　者：Zhaoxia Wang Wangjie Xu Xiuwen Zhao Peng Fang Lianyun Wang Zhongdong Qiao 

机构地区：[1]School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

出　　处：《Acta Biochimica et Biophysica Sinica》2013年第9期792-794,共3页生物化学与生物物理学报（英文版）

基　　金：This work was supported by a grant from Shanghai Natural Science Foundation （08ZR 1410900）.

摘　　要：The failure of insecticides to control pests is becoming more serious around the world. One of the consequences of this failure is that more insecticides are retained in soil, run-off water, and foods as persistent organic pollutants, resulting in severe environmental pollution. So elucidating the pesticide metabolic process of insects has a huge significance. Fenvalerate, a widely used synthetic pyrethroid pesticide that is effective in controlling insect populations, has encoun- tered the rapid development of resistance [1-3]. The cabbage looper （Trichoplusia ni, Tn） is a common crucifer pest that has exhibited resistance to the pyrethroid insecti- cides. In our previous study [4], three P450 monooxygenase isozymes that were functionally connected with the hydrox- ylation reaction in Tn cells were identified in the fenvalerate challenge process. This finding suggested that the P450 might increase the hydrophilicity of fenvalerate by modify- ing its chemical groups.The failure of insecticides to control pests is becoming more serious around the world. One of the consequences of this failure is that more insecticides are retained in soil, run-off water, and foods as persistent organic pollutants, resulting in severe environmental pollution. So elucidating the pesticide metabolic process of insects has a huge significance. Fenvalerate, a widely used synthetic pyrethroid pesticide that is effective in controlling insect populations, has encoun- tered the rapid development of resistance [1-3]. The cabbage looper （Trichoplusia ni, Tn） is a common crucifer pest that has exhibited resistance to the pyrethroid insecti- cides. In our previous study [4], three P450 monooxygenase isozymes that were functionally connected with the hydrox- ylation reaction in Tn cells were identified in the fenvalerate challenge process. This finding suggested that the P450 might increase the hydrophilicity of fenvalerate by modify- ing its chemical groups.

分 类 号：S435.663[农业科学—农业昆虫与害虫防治] TQ453.292[农业科学—植物保护]