解脲支原体的致病性研究进展  

Research progress in pathogenicity of Ureaplasma urealyticum

作　　者：黄珺[1] 张钧[1] 宋铁军[1] 谢鑫友[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院检验科,浙江杭州310016

出　　处：《浙江大学学报（医学版）》2013年第4期464-471,共8页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省卫生厅基金资助项目(2012KYA115);浙江省自然科学基金资助项目(Y2080234);国家自然科学基金资助项目(81171629)

摘　　要：解脲支原体(Ureaplasma urealyticum,UU)是一类与非淋球菌性尿道炎、不孕不育和胎膜早破及新生儿支气管肺泡发育不良等多种疾病相关的病原体。UU的致病性成为近年来的研究热点,主要包括两个方面:其一可能存在的多种潜在的致病因子或致病岛,其二与致病性强弱密切相关的UU的生物群、血清型和浓度及宿主自身的免疫力。文中就UU的致病性进行了详细综述。Ureaplasma urealyticum （UU） is closely related to human diseases including non- gonococcal urethritis （NGU）, infertility, premature membranes and neonatal bronchopulmonary dysplasia. Researches on the pathogenicity of UU have become a hot topic in recent years, and suggest that many potential pathogenicity genes or putative pathogenicity islands are involved in its virulence. Moreover, the biovar and serum types of UU, the infection concentration and the state of the host immune system are also important to determine whether UU can cause human disease or not. In this article the recent progress of researches in the pathogenicity of UU is reviewed.

关 键 词：解脲支原体 毒力 毒力因子类 宿主与病原体相互作用 致病性 致病因子 生物群 血清型 

分 类 号：R375[医药卫生—病原生物学]