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作 者:崔熙娟[1] 李小妹[2] 乔丽娜[1] 单涛[3] 陈鑫[4]
机构地区:[1]西安交通大学医学院第一附属医院普通外科,西安市710061 [2]西安交通大学医学部护理系,西安市710061 [3]西安交通大学医学院第二附属医院普通外科,西安市710004 [4]西安交通大学医学院第一附属医院肝胆外科,西安市710061
出 处:《护理管理杂志》2013年第8期536-538,共3页Journal of Nursing Administration
摘 要:目的系统评价早期肠内营养对促进重症急性胰腺炎预后效果。方法计算机检索2002年至2012年国内外数据库,纳入比较早期肠内营养与全胃肠外营养对重症急性胰腺炎预后效果的随机对照试验,在对纳入研究的偏倚风险进行评价后,进行Meta分析。结果最终纳入16篇文献,共874例患者。Meta分析结果显示,早期肠内营养组和全胃肠外营养组在腹痛缓解时间、血淀粉酶恢复时间、感染发生率、并发症发生率、病死率、住院时间及住院费用方面比较差异具有统计学意义(P<0.01或P<0.05)。结论早期肠内营养有利于重症急性胰腺炎患者病情恢复、改善预后。由于纳入研究方法学质量较低,今后需高质量的大样本随机双盲实验增加论证强度。Objective To systematically review the effect of early enteral nutrition (EN) in promoting prognosis of patients with severe acute pancreatitis (SAP). Methods Electronic databases from 2002 to 2012 were searched to retrieve RCT studies on EN and total parenteral nutrition (TPN) application in patients with severe acute pancreatitis. Bias risks of the studies were evaluated and then Meta analysis was analyzed. Results Sixteen studies of 874 patients were included. Compared with PN,EN was associated with a significantly lower of abdominal pain relief time, serum amylase recovery time,infection risk, complication risk, mortali- ty,length of stay and the cost (P 〈 0.01 or P 〈 0.05). Conclusion Early EN can improve the prognosis of patients with severe acute pancreatitis. Since the recrui- ted studies were weak in study method,it deserves further high quality, big- sample randomized and double -blind trials to enhance the proof strength.
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