免疫吸附治疗重症系统性红斑狼疮患者的护理  

Effect of immunoadsorption treatment on patients with sever systemic lupus erythematosus and its nursing

作　　者：郭粉莲[1] 蔡旭[1] 孔卫红[1] 叶志中[1] 陈新鹏[1] 尹志华[1] 

机构地区：[1]广东医学院附属福田医院香蜜湖风湿病分院风湿科,深圳518040

出　　处：《中华现代护理杂志》2013年第20期2380-2382,共3页Chinese Journal of Modern Nursing

基　　金：深圳市医学重点学科建设资助项目（深卫科发2005C10）;国家＂十一五＂科技支撑计划资助项目（2008BAL59B02）;国家863计划资助项目（012AA02A513）

摘　　要：目的 观察免疫吸附治疗重症系统性红斑狼疮的疗效与不良反应,探讨血浆免疫吸附的护理.方法 收集2009年5月至2012年8月78例重症系统性红斑狼疮患者作为研究对象,将所有患者随机分为治疗组和对照组,治疗组运用免疫吸附配合激素和免疫抑制剂治疗,对照组予以激素和免疫抑制剂治疗.比较两组患者治疗前后系统性红斑狼疮AI评分及相关化验指标的差异.结果 治疗后治疗组各项指标均优于对照组,两组比较,差异有统计学意义（P＜0.05）；如治疗后治疗组白细胞为（6.4±2.3）×109/L,高于对照组的（5.1±2.5）×109/L,治疗组血沉为（20±15）g/L,高于对照组的（17±2.3）g/L,治疗组其余各项指标均与对照组比较,差异有统计学意义（P＜0.05）.结论 严格的治疗前准备、正确操作及密切的观察护理,能提高免疫吸附治疗的安全性和耐受性.Objective To explore the effect and adverse reactions of immunoadsorption treatment on patients with sever systemic lupus erythematosus （SLE） and discuss related nursing.Methods Seventy-eight severe SLE patients from May 2009 to August 2012 were chosen and randomly divided into the treatment group and the control group.The treatment group was treated with immuno-adsorption combined with hormone and immunosuppressant,while the control group was treated with only hormone immunosuppressant.SLEDAI score and laboratorial indexes were compared between two groups before and after the treatment.Results All indexes were better in the treatment group than in the control group after treatment,with statistically significant difference （P〈0.05）.The count of white blood cell and blood sedimentation was respectively（6.4 ±2.3） × 109/L and （20 ± 15） g/L in the treatment group,both higher than （5.1 ± 2.5） x 109/L and （17 ± 2.3） g/L in the control group.Conclusions Strict pre-treatment preparation,proper operation and careful nursing can improve the safety and the tolerability of immunoadsorption treatment.

关 键 词：红斑狼疮 系统性 免疫吸附技术 护理 临床疗效 

分 类 号：R473.5[医药卫生—护理学]