老年冠心病合并肺部感染患者炎性因子指标水平变化  

Change of levels of inflammatory factors in elderly coronary heart disease patients complicated with pulmonary infections

作　　者：陈志刚[1] 孙海燕[2] 席鸿霞[1] 桑文凤[1] 关慧灵[1] 

机构地区：[1]新乡医学院第一附属医院心内科,河南卫辉453100 [2]新乡医学院第三附属医院心内科,河南新乡453000

出　　处：《中华医院感染学杂志》2013年第15期3614-3615,3618,共3页Chinese Journal of Nosocomiology

基　　金：河南省教育厅自然科学研究项目(12A360019)

摘　　要：目的探讨老年冠心病合并肺部感染患者血清白介素6(IL-6)、血清白介素8(IL-8)及瘦素(LP)、超敏C反应蛋白(hs-CRP)水平变化,为其临床研究提供参考依据。方法连续纳入109例老年冠心病合并肺部感染患者(A组),入院时均未合并肺部感染,同时随机抽取健康人群50例(B组),所有受试者均检测IL-6、IL-8、LP及hs-CRP水平,比较感染前后上述指标的变化。结果 A组患者感染前IL-6水平(8.5±1.6)pg/ml、IL-8水平(0.55±0.17)pg/ml、LP水平(8.74±3.56)ng/ml、hs-CRP水平(4.24±1.66)mmol/L;感染后1d分别(9.7±1.8)pg/ml、(0.75±0.18)pg/ml、(9.96±3.66)ng/ml、(11.13±1.55)mmol/L;感染3d后分别为(12.7±1.9)pg/ml、(0.70±0.18)pg/ml、(13.43±3.26)ng/ml、(9.82±1.74)mmol/L;感染后7d分别为(18.5±1.6)pg/ml、(0.65±0.21)pg/ml、(9.44±3.16)ng/ml、(8.51±1.93)mmol/L,均高于B组(7.1±1.3)pg/ml、(0.34±0.14)pg/ml、(5.43±2.94)ng/ml、(2.34±0.54)mmol/L,A组患者感染后1、3、7d血清IL-6、IL-8、LP、hs-CRP水平均高于感染前,差异均有统计学意义(P<0.05)。结论冠心病伴肺部感染发生后,血清IL-6及hs-CRP水平升高更明显,血清IL-8则的感染初期升高明显,感染控制后下降,血清瘦素表现为感染后第3d最高的形式,临床上对上述指标进行监测可以评估患者病情变化。OBJECTIVE To explore the change of levels of IL-6, IL-8 and leptin （LP）, and hs-CRP of the senile coronary heart disease patients complicated with pulmonary infections so as to provide evidence for the clinical study. METHODS A total of 109 elderly coronary heart disease patients complicated with pulmonary infections （the group A） were continuously enrolled in the study, and 50 healthy people （the group B） were randomly select- ed , then the levels of the IL-6, IL-8, leptin （LP）, and hs-CRP of the all the patients were tested, finally the change of the indicators above was compared before and after the infections. RESULTS In the group A, the IL-6 level was （8.5 ±1.6） pg/ml before the infection, the IL-8 level （0.55±0.17） pg/ml, the leptin level （8.74± 3.56） ng/ml, the hs-CRP level （4.24±1.66） retool/L; the IL-6 level was （9.7±1.8） pg/ml one day after the in- fection, the IL-8 level （0.75±0.18） pg/ml, the leptin level （9. 96±3.66） ng/ml, and the hs-CRP level （11.13± 1.55） mmol/L; the IL-6 level was （12.7±1.9） pg/ml three days after the infection, the IL-8 level （0.70±0.18） pg/ml, the leptin level （13.43±3.26） ng/ml, and the hs-CRP level （9. 82±1.74） mmol/L; the IL-6 level was （18.5±1.6） pg/ml seven days after the infection, the IL-8 level （0.65±0.21） pg/ml, the leptin level （9.44 ±3.16） ng/ml, and the hs-CRP level （8.51±1.93） mmol/L, significantly higher than （7.1±1.3） pg/ml of the IL-6, （0.34±0.14） pg/ml of the IL-8, （5.43±2.94） ng/ml of the LP, and （2.34±0.54） mmol/L of the hs- CRP of the group B; the levels of the serum IL-6, IL-8, LP, and hs-CRP of the group A were significantly higher on the first, third, or seventh day after the infections than before the infections, the difference was statistically significant （P〈0.05）. CONCLUSION The levels of serum IL-6 and hs-CRP are elevated more significantly in the coronary heart disease patients complicated with pulmonary infections, the level of

关 键 词：冠心病 肺部感染 白介素6 白介素8 瘦素 超敏C反应蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]