3-甲基-4-氨基-5-乙氧羰基甲硫基三唑席夫碱的合成及生物活性  

Synthesis and Biological Activity of Schiff Base Derivatives 3-Methyl-4-amino-5-ethoxycarbonylmethylthio-1,2,4-triazole

作　　者：杨清翠[1,2] 孙晓红[1,3] 刘源发[4] 靳如意[1] 马海霞[1] 

机构地区：[1]西北大学化工学院,西安710069 [2]西安建筑科技大学理学院,西安710055 [3]西北大学化工学院化学研究所,西安710069 [4]西北大学化学与材料学院,西安710069

出　　处：《化学通报》2013年第8期758-761,共4页Chemistry

基　　金：国家自然科学基金项目(21073141);陕西省自然科学基金项目(2013JK0666)资助

摘　　要：以3-甲基-4-氨基-5-巯基-1,2,4-三唑为原料,在乙醇/氢氧化钠体系中与氯乙酸乙酯反应合成了3-甲基-4-氨基-5-乙氧羰基甲硫基-1,2,4-三唑,再与取代芳醛合成了6种(A1～A6)新型乙氧羰基三唑席夫碱化合物,化合物结构经元素分析,IR,1H NMR,MS等确证。对烟草赤星病、马铃薯干腐病、小麦赤霉病、西瓜枯萎病4种植物病原菌的初步生物活性测试结果表明,化合物A3的抑菌活性优于或相当于对照原药三唑酮。New Shift bases A1 ~ A6 were synthesized by 3-methyl-4-amino-5-ethoxycarbonylmethylthio-1,2,4- triazole with substituted aromatic aldehydes. The intermediate 3-methyl-4-amino-5-ethoxycarbonyl-methyhhio-1,2,4- triazote was synthesized by 3-methyl-4-amino-5-mercapto-1,2,4-triazole with chloroacetic acid ethyl ester in ethanol / sodium hydroxide. The structures were confirmed by 1H NMR, IR, MS. The biological activities of prepared Sehiff bases to four vegetable pathogens have been tested, and the results showed that A3 is better than or equivalent to triadimefon.

关 键 词：席夫碱 5-乙氧羰基甲硫基-1 2 4-三唑 合成 生物活性 

分 类 号：O626.26[理学—有机化学]