广西巴马长寿地区居民血清沉默信号调节蛋白6的表达水平  

Expression level of silent information regulator 6 in serum in Bama longevity area of Guangxi

作　　者：罗兰英[1] 张志勇[1] 黄倩倩[1] 黄永全[1] 覃茜[1] 于洋[1] 农清清[1] 覃健[1] 

机构地区：[1]广西医科大学公共卫生学院职业卫生与环境卫生学教研室,广西南宁530021

出　　处：《环境与健康杂志》2013年第8期693-695,共3页Journal of Environment and Health

基　　金：国家自然科学基金(81060246;81260423);广西自然科学基金(2011GXNSFD018029);广西科学基金(桂科青0832032;桂科自0991115);广西科学研究与技术开发项目(桂科能0815011-6-5);高等学校博士学科点专项科研基金(20104503110005)

摘　　要：目的了解广西巴马地区居民血清沉默信号调节蛋白6（silentinformationregulator6，sIRT6）蛋白表达水平的差异，探讨其与家庭聚集性长寿现象的关系。方法于2011年5—6月，在巴马地区单纯随机抽取有3—4代直系亲属的家庭分为长寿家族史组共137例（年龄30～106岁，男70人，女67人）和非长寿家族史组共91例（年龄22—89岁，男51人，女40人）。测定血压、血生化指标[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、空腹血糖（FPG）1和血清sIRT6蛋白表达水平。结果长寿家族史组血清TC、TG和HDL含量均低于非长寿家族史组（P〈0．05，P〈0．01）。长寿家族史组血清中SIRT6表达水平低于非长寿家族史组（P〈0．05）。经单因素分析，长寿家族史组血清sIRT6蛋白水平与年龄、FPG含量呈正相关（P〈0．05），与TG含量呈负相关（P〈0．05）；而非长寿家族史组血清SIRT6蛋白水平仅与年龄呈负相关（P〈0．05）。结论血清sIRT6蛋白表达水平可能与巴马地区家庭聚集性长寿现象存在一定联系。Objective To know the difference in people＇s serum level of silent information regulator 6 （SIRT6） in Bama area of Guangxi and explore the association between that and familial aggregation of longevity phenomenon. Methods In May to June, the families which had 3-4 generations of immediate family members were randomly chosen and sorted into longevity group which had 137 people（aged 30-106 years, male 70,female 67） and no- longevity group which had 91 people（aged 22- 89 years, male 70, female 67） in Bama area. The blood pressure, serum biochemical indexes[total cholesterol （TC）, triglycerides （TG） ,high density lipoprotein （HDL）,low density lipoprotein （LDL）,fasting plasma glucose （FPG）] and the serum level of SIRT6 protein were determined. Results The serum levels of TC,TG and HDL in longevity group were lower than those of non-longevity group （P〈0.05,P〈0.01）. The serum level of SIRT6 protein in longevity group was lower than that of non- longevity group （P〈0.05）. Single factor analysis showed that the serum level of SIRT6 was positively correlated to people＇s age and fasting plasma glucose level,and was negatively correlated to triglyceride （P〈0.05） in the long-live group;While in the non-long-live group, that the serum level of SIRT6 was only negatively correlated to people＇s age （P〈0.05）. Conclusion The expression of SIRT6 in serum may be involved in familial aggregation of longevity phenomenon in Bama country.

关 键 词：沉默信号调节蛋白6 长寿 巴马地区 

分 类 号：R994.6[医药卫生—毒理学]