动物结缔组织中超分子胶原液晶结构研究进展  

Progress on Structures of Supermolecular Collagenous Liquid Crystal in Animal Connective Tissue

作　　者：李莉莉[1] 陈露[1] 李霞[1] 孙鹏[1,2,3] 郝娜[1] 蒋波[1] 

机构地区：[1]四川大学生物材料工程研究中心国家生物医学材料工程技术研究中心,成都610064 [2]四川大学原子核科学技术研究所教育部核技术重点实验室,成都610064 [3]武警警官学院数学与物理学系,成都610213

出　　处：《高分子通报》2013年第8期36-44,共9页Polymer Bulletin

摘　　要：动物结缔组织的发生、发育及病变与结构和形态密切相关,组织结构有序性在结缔组织发生过程中尤为明显,结缔组织的胶原液晶结构是胶原分子自组装得到胶原纤维或组织过程中的一个过渡态。本文以重建胶原为基础分子,讨论了三螺旋结构对胶原分子组装液晶的影响,并分析了胶原分子液晶和超分子液晶结构转变研究进展和形成的热、动力学条件。诱导胶原液晶形成是体外模拟细胞外基质构建的关键,为研究结缔组织形态发生机制及病变模型建立了联系,也为仿生构建组织工程支架提供有益信息。The occurrence, development and pathological changes of animal connective tissue are closely related to their structures and morphologies, and particularly the orderliness on the structure of tissue is apparent, liquid crystalline structures of collagen in connective tissue are a transition state that collagen molecules self-assemble into collagen fibers or tissue. Based on reconstituted collagen molecules, we have discussed that triple helical structure has an impact on collagen molecules assembling into liquid crystal, and have analyzed research progress on structural transformation of collagen molecular liquid crystal and super-molecular liquid crystal, as well as thermal and dynamic forming conditions. Inducing the formation of collagen liquid crystal is the key to simulate construction of the extracellular matrix in vitro. It not only established contact for studying the mechanisms of connective tissue morphogenesis and pathological process, but also provided useful information for building tissue engineering scaffolds.

关 键 词：胶原分子 熵致有序 分子液晶 超分子液晶 结缔组织 

分 类 号：Q954.6[生物学—动物学]